INTRODUCTION Alterations in voltage-gated sodium channel (VGSC) function have been linked to chronic pain and are good targets for analgesics. Lacosamide (LCM) is a novel anticonvulsant that enhances the slow inactivation state of VGSCs. This conformational state can be induced by repeated neuronal firing and/or under conditions of sustained membrane depolarisation, as is expected for hyperexci...

PURPOSE The goal of this study is to report the efficacy and tolerability of lacosamide (LCM) monotherapy, as first-line and conversion regimens, in the treatment of patients with partial-onset seizures. METHODS We retrospectively reviewed the charts of patients with focal epilepsy on LCM monotherapy from six centers in Spain. Efficacy and tolerability were evaluated in the overall group and ...

In neonatal or congenital lymphocytic choriomeningitis (LCM) virus carrier mice, low numbers of T lymphocytes were always infected, but attempts to infect resting or stimulated T lymphocytes in previously uninfected adult mice have consistently failed. Only T cells in newborn mice were susceptible to LCM virus and their infection persisted when the animals grew older. Infectibility declined wit...

Let e and n be positive integers and S = {x1, . . . , xn} be a set of n distinct positive integers. The n × n matrix having eth power [xi, xj ] of the least common multiple of xi and xj as its (i, j)-entry is called the eth power least common multiple (LCM) matrix on S, denoted by ([S]). The set S is said to be gcd closed (respectively, lcm closed) if (xi, xj) ∈ S (respectively, [xi, xj ] ∈ S) ...

ABSTRACT: 10 Owing to the complexity of neurodegenerative diseases, multiple cellular types need to be targeted 11 simultaneously in order for a given therapy to demonstrate any major effectiveness. Ultrasound12 sensitive coated microbubbles (in a targeted nanoemulsion) are available. Versatile small-molecule 13 drug(s) targeting multiple pathways of Alzheimer's disease pathogenesis are known. ...

Let e and n be positive integers and S = {x1, . . . , xn} be a set of n distinct positive integers. The n × n matrix having eth power [xi, xj ] of the least common multiple of xi and xj as its (i, j)-entry is called the eth power least common multiple (LCM) matrix on S, denoted by ([S]). The set S is said to be gcd closed (respectively, lcm closed) if (xi, xj) ∈ S (respectively, [xi, xj ] ∈ S) ...

introduction there is very limited literature describing the association of lateral condyle mass (lcm) fracture of the distal humerus associated concurrently with olecranon fracture. herein, a case is reported of a displaced lcm fracture with displaced olecranon fracture, due to complex trauma while getting out of a vehicle, which was managed by open reduction and internal fixation. conclusions...

s t lcm lcm*2 lcm*4 gcd gcd/2 gcd/4 s t lcm lcm*2 lcm*4 gcd gcd/2 gcd/4 Table 1: Execution times (ms) for cyclic(s) to cyclic(t) redistribution on 32 processors. other block sizes t. Fig. 3 shows the total times in milliseconds for a cyclic(192) to cyclic(8) redistribution on 32 processors for increasing data sizes. This redistribution corresponds to the cyclic(Y t) to cyclic(t) case with Y = 2...

Laser capture microdissection (LCM) has become an important tool in biological research, permitting isolation of specific cell populations from frozen tissue samples containing a mixture of cell types. Cells obtained by LCM can be directly analyzed by matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS). We report here methodology for the preparation and analysis of LCM capt...

Magnified endoscopic observation of the gastrointestinal tract has become possible. However, such observation at the cellular level remains difficult. Laser-scanning confocal microscopy (LCM) is a novel, noninvasive optical imaging method that provides instant microscopic images of untreated tissue under endoscopy. We compare prototype catheter-based reflectance-type LCM images in vivo and hist...