Mivacurium is metabolized by plasma cholinesterase (PCHE). Metoclopramide inhibits PCHE in vitro and in vivo. We have assessed the effect of metoclopramide on duration of action of mivacurium and measured PCHE at baseline and at the time of maximal block. In a randomized, double-blind study, 30 patients received metoclopramide 0.15 mg kg-1 i.v. or saline, followed by propofol anaesthesia and mi...

PURPOSE To evaluate the effects of metoclopramide on metalloproteinases (MMP) and interleukins (IL) gene expression in colonic anastomoses in rats. METHODS Eighty rats were divided into two groups for euthanasia on the 3rd or 7th postoperative day (POD), then into two subgroups for sepsis induction or not, and then into subgroups to receive either metoclopramide or saline solution. Left colon...

High dose metoclopramide infusions (10 mg/kg) were administered to nineteen patients with bronchial carcinoma who were receiving intravenous cyclophosphamide as single agent chemotherapy. Considerable interindividual variability in metoclopramide disposition was observed. Mean clearance was 0.33 +/- 0.13 (s.d.) l h-1 kg-1, mean volume of distribution at steady state was 3.8 +/- 1.2 (s.d.) l/kg ...

OBJECTIVE To investigate the effect of the rate of metoclopramide infusion on akathisia incidence, severity, onset of symptoms, and duration in patients with headache, and/or nausea/vomiting in the emergency department (ED) setting. METHODS Prospective, double blind, randomised clinical study comparing two rates of intravenous infusion of metoclopramide over a period of six months at a tertia...

Vahabi S1, Ghafarzade M2, Lorzade N2, Moradkhani MR1, Frazan B1, Geranghadr P3 1. Assistant professor, Department of anesthesiology, Faculty of medicine, Lorestan University of medical sciences 2. Assistant professor, Department of gynecology, Faculty of medicine, Lorestan University of medical sciences 3. General practitioner Abstract Background: Postoperative nausea, vomiting (P...

BACKGROUND Dopaminergic and opioidergic drugs have been found to be effective in patients with restless legs syndrome (RLS). OBJECTIVES To test the effect of apomorphine--a combined opioidergic and dopaminergic agonist--and subsequent selective antagonism by naloxone and metoclopramide on subjective and objective symptoms in patients with idiopathic RLS. METHODS Nine patients with RLS were ...

Dear editor I would like to congratulate the authors of the article entitled, “Optimal management of nausea and vomiting of pregnancy” for the comprehensive review of treatments for a frequent complication of pregnancy. Although this letter arrives well after publication I think it is important for researchers in the future to have clarification on one seemingly minor but important point. In or...

Introduction: Articles pertaining to reports and clinical or pharmacological research for cardiovascular adverse effects of metoclopramide were identified via a search of MEDLINE (1966­February 2012), SCOPUS, and Google Scholar. Objective: To review the reports in literature of patients receiving metoclopramide who sufferred from cardiac arrest, bradycardia, total heart block, acute hypotension...