Background: Non-small-cell lung cancer has a relatively high remission rate for initial chemotherapy. However, it is very liable to appear adoptive resistance. Irradiated tumor cells modified with GM-CSF are very effective in triggering immune responses. Therefore, combined therapy of tumor cell vaccine expressing GM-CSF with chemotherapy for NSCLC should be focused on. Objectives: To study the...

Cachexia is defined as an excessive, involuntary loss of fat and lean tissue. We tested the validity of the Lewis lung carcinoma (LLC) as a model of cancer cachexia and examined its effect on the two major lean tissue components, skeletal muscle and bone. LLC cells (0.75 × 10(6)) were injected into the left thigh of C57BL/6 mice. Control mice received an equal volume injection of growth media. ...

llc is a language designed to extend OpenMP to distributed memory systems. Work in progress on the implementation of a compiler that translates llc code and targets distributed memory platforms is presented. Our approach generates code for communications directly on top of MPI. We present computational results for two different benchmark applications on a PC-cluster platform. The results reflec...

From previous discussion, the power stage could be designed according to the given specifications. The outcome of the design is the desired values for the components. For these components, power devices and capacitors are obtained from manufactures, which already reflect the state of the art technology. Within all these components, magnetic is the one need to be physically designed and built by...

The in vitro and in vivo effects of prostaglandin E2 (PGE2) and of its stable analogue, 16,16-dimethyl-PGE2 (dmPGE2), on myelopoiesis and on the myelopoiesis-associated immune suppressor cell activity of mice bearing metastatic variant Lewis lung carcinoma (LLC-C3) tumors are assessed. In vitro studies showed a reduced susceptibility of bone marrow myeloid progenitor cells (CFC) from LLC-C3 tum...

Chondroitin sulfate (CS) containing E-disaccharide units, glucuronic acid-N-acetylgalactosamine(4, 6-O-disulfate), at surfaces of tumor cells plays a key role in tumor metastasis. However, the molecular mechanism of the metastasis involving the CS chain-containing E-units is not fully understood. In this study, to clarify the role of E-units in the metastasis and to search for potential molecul...

Mesenchymal stem cells (MSCs) can be used as a therapeutic armor for cancer. Extracellular vesicles (EVs) from MSCs have been evaluated for anticancer effects. In vivo targeting of EVs to the tumor is an essential requirement for successful therapy. Therefore, non-invasive methods of monitoring EVs in animal models are crucial for developing EV-based cancer therapies. The present study to devel...

The series–parallel resonant converter (also called line level control (LLC) resonant converter) is one of the most suitable topologies for dc–dc power supply. This study introduces the LLC resonant converter into the on-board battery chargers for the plug-in hybrid electric vehicle (PHEV) applications. Different from the previous literature which has focused on the wide operation range and hol...

Phorbol 12-myristate 13-acetate (PMA) decreases the tight junction conductance (TJC) during the reorganization of LLC-PK1A monolayers, but has the opposite effect in LLC-PK1B4, MDCK, and MDCK4 cells. Because no protein synthesis was required for the effects of PMA on the TJC of LLC-PK1A monolayers, we conclude that the regulation of the tight junction by protein kinase C (PKC) is a posttranslat...