BACKGROUND Recent studies showed that inappropriate expression of microRNAs (miRNAs) is strongly associated with tumor-related processes in humans (2-9,11-17). OBJECTIVE To understand the changes of miRNAs in endometriosis. MATERIALS AND METHODS With real-time RT-PCR, we investigated the miR-143 and miR-145 expression in eutopic (EU, n=2) and ectopic endometrium (EC, n=11) (from women with ...

PURPOSE NY-ESO-1 (ESO), a tumor-specific antigen of the cancer/testis group, is presently viewed as an important model antigen for the development of generic anticancer vaccines. The ESO(119-143) region is immunodominant following immunization with a recombinant ESO vaccine. In this study, we generated DRB1*0101/ESO(119-143) tetramers and used them to assess CD4 T-cell responses in vaccinated p...

Thanh Tung Nguyen a,c, Nam Seo Goo b,c,∗,1, Vinh Khanh Nguyen c, Youngtai Yoo d, Seungbae Park e a Department of Aerospace Engineering, Konkuk University, Gwangjin-gu, Seoul 143-701, Republic of Korea b Smart Microsystem Research Laboratory, Department of Advanced Technology Fusion, Konkuk University, Gwangjin-gu, Seoul 143-701, Republic of Korea c Artificial Muscle Research Center and Smart Ro...

Elevated levels of insulin-like growth factor-I (IGF-I) are associated with carcinogenesis and cancer progression. However, the molecular mechanisms by which IGF-I promotes prostate cancer development remain to be elucidated. Docetaxel chemotherapy is an important therapeutic strategy in many types of human cancers including prostate cancer. In this study, we showed that IGF-I rendered PC-3 and...

Colorectal cancer is one of the most commonly diagnosed cancers and a leading cause of death. Studies have shown that abnormal expression of microRNAs, small non-coding RNA molecules that regulate gene expression, is linked to the occurrence of cancer. This study sought to determine the role of microRNA-143 (miR-143) in colorectal cancer. Reduced levels of miR-143 expression were detected in co...

Immunity to 143/140 kD schizont antigens of a monkey malaria, Plasmodium knowlesi, provides partial protection to lethal malaria infection in rhesus monkeys challenged with uncloned parasites. To determine the capacity of a cloned parasite to generate variants of the 143/140 kD antigens, immunized monkeys were challenged with a clone of P. knowlesi. Parasites recovered 8 d after inoculation wit...

MicroRNAs (miRNAs) have emerged as potential anticancer agents, but their clinical application is limited by the lack of an effective delivery system to tumors. Exosomes are small vesicles that play important roles in intercellular communication. Here, we show that synthetic miR-143 introduced into cells is released enveloped in exosomes and that the secreted exosome-formed miR-143 is transferr...

The technical and clinical success rates of endovascular The Primary Patency and Fracture Rates of SelfExpandable Nitinol Stents Placed in the Popliteal Arteries, Especially in the P2 and P3 Segments, in Korean Patients Il Soo Chang, MD, Hyun Keun Chee, MD, Sang Woo Park, MD, Ik Jin Yun, MD, Jae Joon Hwang, MD, Song Am Lee, MD, Jun Seok Kim, MD, Seong-Hwan Chang, MD, Hong Geun Jung, MD Departme...