Harada, Shuitsu, and Yasuo Kasahara. Inhibitory effect of gurmarin on palatal taste responses to amino acids in the rat. Am J Physiol Regulatory Integrative Comp Physiol 278: R1513–R1517, 2000.—Gurmarin (10 μg/ml), a protein extracted from Gymnema sylvestre, depressed significantly (40–50%) the phasic taste responses to sugars (sucrose, fructose, lactose, and maltose) and saccharin sodium recor...

Tolbert, Evelyn M., Joseph Weisstuch, Helen D. Feiner, and Lance D. Dworkin. Onset of glomerular hypertension with aging precedes injury in the spontaneously hypertensive rat. Am J Physiol Renal Physiol 278: F839– F846, 2000.—The changes in renal hemodynamics that develop with aging in spontaneously hypertensive rats (SHR) were examined. Micropuncture studies revealed that glomerular capillary ...

Vink, Hans, and Brian R. Duling. Capillary endothelial surface layer selectively reduces plasma solute distribution volume. Am. J. Physiol. Heart Circ. Physiol. 278: H285– H289, 2000.—We previously reported that a 0.4to 0.5-μmthick endothelial surface layer confines Dextran 70 (70 kDa) to the central core of hamster cremaster muscle capillaries. In the present study we used a variety of plasma ...

Ishine, Takaaki, Isabelle Bouchelet, Edith Hamel, and Tony J. F. Lee. Serotonin 5-HT7 receptors mediate relaxation of porcine pial veins. Am. J. Physiol. Heart Circ. Physiol. 278: H907–H912, 2000.—Isolated porcine pial veins in the presence of active muscle tone have been shown to exhibit rhythmic contractions (RC) that are inhibited by serotonin (5-HT) in a concentration-dependent manner. The ...

Naghashpour, M., and G. Dahl. Sensitivity of myometrium to CGRP varies during mouse estrous cycle and in response to progesterone. Am. J. Physiol. Cell Physiol. 278: C561–C569, 2000.—Calcitonin gene-related peptide (CGRP) inhibits contractions of the myometrium. Isometric force measurements on myometrial strips were carried out to monitor the inhibitory capacity of CGRP in the myometrium during...

Munzenmaier, Diane H., and David R. Harder. Cerebral microvascular endothelial cell tube formation: role of astrocytic epoxyeicosatrienoic acid release. Am J Physiol Heart Circ Physiol 278: H1163–H1167, 2000.—Cerebral microvascular endothelial cells (CMVEC) form tubes when cocultured with astrocytes (AS). Therefore, it appears that AS may be important in mediating angiogenesis in the brain. We ...

Toyoda, Kazunori, Frank M. Faraci,Andrew F. Russo, Beverly L. Davidson, and Donald D. Heistad. Gene transfer of calcitonin gene-related peptide to cerebral arteries. Am. J. Physiol. Heart Circ. Physiol. 278: H586–H594, 2000.—Overexpression of calcitonin gene-related peptide (CGRP), an extremely potent vasodilator, to blood vessels is a possible strategy for prevention of vasospasm. We construct...

Kuryshev, Yuri A., Tatyana I. Gudz, Arthur M. Brown, and Barbara A. Wible. KChAP as a chaperone for specific K1 channels. Am J Physiol Cell Physiol 278: C931–C941, 2000.—The concept of chaperones for K1 channels is new. Recently, we discovered a novel molecular chaperone, KChAP, which increased total Kv2.1 protein and functional channels in Xenopus oocytes through a transient interaction with t...

Johnston, Sonya D., Sandra Orgeig, Olga V. Lopatko, and Christopher B. Daniels. Development of the pulmonary surfactant system in two oviparous vertebrates. Am. J. Physiol. Regulatory Integrative Comp. Physiol. 278: R486– R493, 2000.—In birds and oviparous reptiles, hatching is often a lengthy and exhausting process, which commences with pipping followed by lung clearance and pulmonary ventilat...

JOHN G. HOHMANN,1 THOMAS H. TEAL,2 DONALD K. CLIFTON,2 JAMES DAVIS,3 VICTOR J. HRUBY,4 GUOXIA HAN,4 AND ROBERT A. STEINER2,5 1Graduate Program in Neurobiology and Behavior, Departments of 2Obstetrics and Gynecology and 5Physiology and Biophysics, University of Washington, Seattle, Washington 98195; 3Amgen Corporation, Thousand Oaks, California 91320; and 4Department of Chemistry, University of ...