The benzyloxy-substituted lactone cyclooxygenase-2 inhibitor DFB [3-[(3,4-difluorobenzyl)oxy]-5,5-dimethyl-4-[4-(methylsulfonyl)phenyl]furan-2(5H)-one] is metabolized in human and rat liver microsomal incubations and hepatocytes to a fluorescent metabolite, DFH [3-hydroxy-5,5-dimethyl-4-[4-(methylsulfonyl)phenyl]furan-2(5H)-one]. This process is CYP3A-mediated in both species, as demonstrated b...

We report the InAs/GaAs quantum dot laterally coupled distributed feedback (LC-DFB) lasers operating at room temperature in wavelength range of 1.31 µm. First-order chromium Bragg gratings were fabricated alongside ridge waveguide to obtain maximum coupling coefficient with optical field. Stable continuous-wave single-frequency operation has been achieved output power above 5 mW/facet and side ...

A terahertz master-oscillation power-amplifier quantum cascade laser (THz-MOPA-QCL) is demonstrated where a grating coupler is employed to efficiently extract the THz radiation. By maximizing the group velocity and eliminating the scattering of THz wave in the grating coupler, the residue reflectivity is reduced down to the order of 10-3. A buried DFB grating and a tapered preamplifier are prop...

We have developed an efficient and compact 3.4 μm difference-frequency-generation spectrometer using a 1.55 μm distributed feedback (DFB) laser diode, a 1.06 μm DFB laser diode, and a ridge-waveguide periodically poled lithium niobate. It is continuously tunable in the 30 cm(-1) span and is applied to (12)CH(3)D/(12)CH(4) isotope ratio measurements. The suitable pair of (12)CH(3)D ν(4) (p)P(7,6...

The metabotropic glutamate receptor subtype 5 (mGluR5) activates calcium mobilization and extracellular signal-regulated kinase 1/2 (ERK1/2) phosphorylation in cortical astrocytes. These are independent signaling systems, and they can be differentially regulated. We recently discovered two novel selective allosteric potentiators of mGluR5, 3,3'-difluorobenzaldazine (DFB) and N-{4-chloro-2-[(1,3...

Drynaria fortunei (KUNZE) J. SM. (DFE) is one of the most frequently used traditional Chinese medicines prescribed for the treatment of osteoporosis in China. The present study was designed to investigate the osteoprotective constituents from Drynaria fortunei. The 60% ethanol extract of the rhizome of D. fortunei (DFE) was chromatographed on a D-101 macroporous resin column (psi 25x150 cm); th...

This article proposes an adaptive coded modulation (ACM) with multi-levels qualities of service analysis, which can be used to perform physical layer functions in software radio receivers for beyond third generation systems. ACM approche employs multiple coding and modulation schemes in order to adapt instantaneously spectral efficiency to the signal-to-noise ratio variations SNR. The idea is t...

The integration of organic semiconductor distributed feedback (DFB) laser sources into all-polymer chips is promising for biomedical or chemical analysis. However, the fabrication of DFB corrugations is often expensive and time-consuming. Here, we apply the method of laser-assisted replication using a near-infrared diode laser beam to efficiently fabricate inexpensive poly(methyl methacrylate) ...

Technologies for creating microresonators based on the effect «whispering gallery modes» (WGM) and distributed feedback (DFB) lasers used in an optoelectronic generator (OEO) are investigated generalized. The calculation of natural frequencies WGM resonator DFB laser is presented. Software modeling electromagnetic field distribution MATLAB environment implemented. An approach to manufacturing t...