Perinatal hypoxia/ischemia (HI) is a common cause of neurological deficits in children. Our goal was to elucidate the underlying mechanisms that contribute to the neurological sequelae of HI-induced brain injury. HI was induced by permanent ligation of the left carotid artery followed by 90 min of hypoxia (7.8% O2) in female P7 rats. A two-dimensional differential proteome analysis was used to ...

BACKGROUND Screening tests are available to determine immunity to vaccine-preventable diseases, such as mumps and rubella. We aimed to define better assay for detecting immune status of health care personnel to vaccine-preventable diseases. METHODS Mumps and rubella antibodies of health care personnel at Shimane University Hospital were examined by hemagglutination inhibition assay (HI), comp...

The Arecibo Legacy Fast ALFA (ALFALFA) survey is a program aimed at obtaining a census of HI-bearing objects over a cosmologically significant volume of the local universe. When complete in ∼3–4 years, it will cover 7000 square degrees of high latitude sky using the 305 m telescope and the seven-beam Arecibo L-band feed array (ALFA). As of May 1, 2008, almost 60% of the required observations ar...

When is the composition of paraproducts bounded? This is an important, and difficult question. We consider randomized variants of this question, finding non-classical characterizations. For dyadic interval I, let hI = h 0 I be the L-normalized Haar function adapted to I, the superscript 0 denoting that it has integral zero. Set h I = |hI |, the superscript 1 denoting a non-zero integral. A (cla...

BACKGROUND Cerebral hypoxia/ischemia (HI) is not uncommon during the perinatal period. If occurring, it can result in severe neurologic disabilities that persist throughout life. Salvinorin A, a non-opioid Kappa opioid receptors (KOR) selective agonist, has the potential to address this devastating situation. We have demonstrated that salvinorin A administration before HI, preserves pial artery...

While B cells are generally considered to be positive regulators of humoral immune responses due to their ability to differentiate into plasmablasts/plasma cells and produce antibodies, B cells also modulate immune responses through antigen presentation and cytokine secretion. Moreover, "regulatory B cells" that suppress immune responses have been recognized as an important new component of the...

We estimate the number of old, radiative supernova remnants (SNRs) detectable in Hi 21-cm emission line in the Galaxy. We assume that old SNRs consist of expanding Hi shells and that they are visible if the line-of-sight velocities are sufficiently outside the velocity range of the Galactic background Hi emission. This criterion of visibility makes it possible to calculate the background contam...

Use of formal methods in verification activities for critical software development is a promising solution to increase the level of confidence compared to the current practice based on testing, for increasingly complex programs, at a lower cost than the current approach. Concretely, the upcoming standard DO-178C for software development in avionics gives credit to formal verification for suppor...