95 THE CANADIAN HIGHWAY NETwork consists mainly of two-lane highways where passing slower cars requires traveling in the lane assigned to the opposite traffic. Therefore, studying the mechanism of the passing maneuver is important for maintaining traffic safety, as well enhancing the highway’s level of service. Models for passing maneuvers are available in the design guides1,2 while different v...

To address the unsolved question of PSD-95 function I used short hairpin RNA (shRNA) to knock-down protein expression. shRNA mediated knock-down of protein expression is one of the established methods exploiting the naturally occurring expression control mechanism known as RNA interference (RNAi). Cells express shRNAs that are complementary to the mRNA they control. The shRNAs are processed and...

We evaluated the efficacy, potency, and selectivity of the three most commonly used adenylate cyclase (AC) inhibitors in a battery of cell lines constructed to study signaling via three discrete cAMP sensors identified in neuroendocrine cells. SQ22,536 [9-(tetrahydrofuryl)-adenine] and 29,59-dideoxyadenosine (ddAd) are effective and potent AC inhibitors in HEK293 cells expressing a cAMP respons...

Background. Rocabado’s hyoid triangle is the only cephalometric parameter that can assess the effects of orthodontic treatment on tongue posture. Aim. To evaluate the restoration of tongue posture and function by conducting a cephalometric assessment of the hyoid triangle before and after rapid maxillary expansion. Methods. Sixtyfour healthy patients aged 6-11 years with skeletal class II maloc...

Chronic myelogenous leukemia (CML) is a myeloproliferative disorder characterized at the molecular level by the expression of Bcr-abl, a 210-kDa fusion protein with deregulated tyrosine kinase activity. Encouraged by the clinical validation of Bcr-abl as the target for the treatment of CML by imatinib, we sought to identify pharmacological agents that could target this kinase by a distinct mech...

Omnivorous Heteroptera constitute an important component of predatory guilds with high potential for biological control. Understanding the relative effects of plant feeding on the suppression of prey by omnivores could be an important element for improving biological control strategies. In the current paper, the effects of different plant food sources on the predation rate of the omnivorous pre...