The epidermal growth factor receptor (EGFR) family has been implicated in several cancers, including breast, and its members have become the target of novel cancer therapies. In this report, we show a novel link between erlotinib, a potent EGFR inhibitor, DNA damage, and homology-directed recombinational repair (HDR) in human breast cancer cells. Erlotinib suppresses HDR. This is not secondary ...

High Dynamic Range (HDR) images use a wider range of intensity values than the common Limited Dynamic Range (LDR) images. Because of this, handling HDR images requires a great deal of information to be stored and transferred. To represent and display HDR images efficiently, a trade-off needs to be balanced between size and accuracy. We present a new wavelet-based algorithm for encoding HDR imag...

High quality video sequences are required for the evaluation of tone mapping operators and high dynamic range (HDR) displays. We provide scenic and documentary scenes with a dynamic range of up to 18 stops. The scenes are staged using professional film lighting, make-up and set design to enable the evaluation of image and material appearance. To address challenges for HDR-displays and temporal ...

We presented a survey on High-dynamic-range imaging (HDRI or HDR) is a set of methods used in the imagingand photography to reproduce a superior dynamic range of luminosity than regular digital imaging or photographic methods can do. HDR images can denote a superior range of the luminance levels than can be attained using the extra 'classical' techniques. Images such as those holding many actua...

Our High-Dynamic-Range (HDR) world is the result of nonuniform illumination. We like to believe that 21st century technology makes it possible to accurately reproduce any scene. On further study, we find that scene rendition remains a best compromise. Despite all the remarkable accomplishments in digital imaging, we cannot capture and reproduce the light in the world exactly. With still further...

In this paper, we propose a novel deep neural network model that reconstructs a high dynamic range (HDR) image from a single low dynamic range (LDR) image. The proposed model is based on a convolutional neural network composed of dilated convolutional layers, and infers LDR images with various exposures and illumination from a single LDR image of the same scene. Then, the final HDR image can be...

Muscle sympathetic nerve activity (MSNA) is altered by vestibular otolith stimulation. This study examined interactive effects of the vestibular system and baroreflexes on MSNA in humans. In study 1, MSNA was measured during 4 min of lower body negative pressure (LBNP) at either -10 or -30 mmHg with subjects in prone posture. During the 3rd min of LBNP, subjects lowered their head over the end ...

Crowdsourcing is becoming a popular cost effective alternative to lab-based evaluations for subjective quality assessment. However, crowd-based evaluations are constrained by the limited availability of display devices used by typical online workers, which makes the evaluation of high dynamic range (HDR) content a challenging task. In this paper, we investigate the feasibility of using low dyna...

BACKGROUND Hypoparathyroidism-deafness-renal dysplasia (HDR) syndrome is an autosomal dominant disorder primarily caused by haploinsufficiency of GATA binding protein 3 (GATA3) gene mutations, and hearing loss is the most frequent phenotypic feature. This study aimed at identifying the causative gene mutation for a three-generation Chinese family with HDR syndrome and analyzing auditory phenoty...

DNA double-strand breaks (DSBs) are the most severe type of DNA damage. DSBs are repaired by non-homologous end-joining or homology directed repair (HDR). Identifying novel small molecules that affect HDR is of great importance both for research use and therapy. Molecules that elevate HDR may improve gene targeting whereas inhibiting molecules can be used for chemotherapy, since some of the can...