نتایج جستجو برای: شاخص ed50

تعداد نتایج: 76082  

Journal: :anesthesiology and pain medicine 0
fatemeh zeraati department of pharmacology, hamedan university of medical sciences, hamedan, iran; department of pharmacology, hamedan university of medical sciences, hamedan, iran. tel: +98-9183122063, fax: +98-8118226035 malihe araghchian department of pharmacology, hamedan university of medical sciences, hamedan, iran mohammad hadi farjoo department of pharmacology, hamedan university of medical sciences, hamedan, iran

background combining different analgesic drugs for improvement of drug efficacy is a recommended strategy intended to achieve the optimal therapeutic effects. objectives the purpose of the present study was to assess the nature of the interaction between ascorbic acid and two analgesic drugs, morphine and tramadol. materials and methods the analgesic activity was assessed by the acetic acid wri...

Journal: :Agronomy 2022

Pelargonic acid is a non-selective post-emergence contact bio-herbicide which registered both for cropping and non-cropping uses in several countries. Dose–response curves on the efficacy of pelargonic against common weeds Mediterranean areas are not available. summer winter annual were evaluated two field experiments (winter exp. 2019 2020) central Italy. was applied at five doses (1.4, 2.7, 5...

2013
Su Jin Kim Ming-Qiang Zheng Nabeel Nabulsi David Labaree Jim Ropchan Soheila Najafzadeh Richard E. Carson Yiyun Huang Evan D. Morris

11C-LY2795050 is a novel k-selective antagonist PET tracer. The in vitro binding affinities (Ki) of LY2795050 at the k-opioid (KOR) and m-opioid (MOR) receptors are 0.72 and 25.8 nM, respectively. Thus, the in vitro KOR/MOR binding selectivity is about 36:1. Our goal in this study was to determine the in vivo selectivity of this new KOR antagonist tracer in the monkey. Methods: To estimate the ...

2013
Thomas Christoph Wolfgang Schröder Ronald J. Tallarida Jean De Vry Thomas M. Tzschentke

Tapentadol is a m-opioid receptor (MOR) agonist and norepinephrine reuptake inhibitor (NRI) with established efficacy in neuropathic pain in patients and intrinsic synergistic interaction of both mechanisms as demonstrated in rodents. In diabetic mice, we analyzed the central antihyperalgesic activity, the occurrence of site-site interaction, as well as the spinal contribution of opioid and nor...

Journal: :The Journal of physiology 2003
M A Hollywood Siobhan Woolsey I K Walsh P F Keane N G McHale K D Thornbury

The purpose of the present study was to characterise Ca2+ currents in smooth muscle cells isolated from biopsy samples taken from the proximal urethra of patients undergoing surgery for bladder or prostate cancer. Cells were studied at 37 degrees C using the amphotericin B perforated-patch configuration of the patch-clamp technique. Currents were recorded using Cs+-rich pipette solutions to blo...

Journal: :Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2013
Su Jin Kim Ming-Qiang Zheng Nabeel Nabulsi David Labaree Jim Ropchan Soheila Najafzadeh Richard E Carson Yiyun Huang Evan D Morris

UNLABELLED (11)C-LY2795050 is a novel κ-selective antagonist PET tracer. The in vitro binding affinities (Ki) of LY2795050 at the κ-opioid (KOR) and μ-opioid (MOR) receptors are 0.72 and 25.8 nM, respectively. Thus, the in vitro KOR/MOR binding selectivity is about 36:1. Our goal in this study was to determine the in vivo selectivity of this new KOR antagonist tracer in the monkey. METHODS To...

Journal: :Canadian journal of anaesthesia = Journal canadien d'anesthesie 1997
R D Stein S B Backman B Collier C Polosa

PURPOSE The bradycardia produced by pyridostigmine and physostigmine in an animal model of acute cardiac denervation was examined according to its relation to cholinesterase inhibition and sensitivity to block by cholinergic receptor antagonists. METHODS Cats were anaesthetised, vagotomised and propranolol-treated. Heart rate was continuously recorded. Erythrocyte cholinesterase activity of a...

2014
Fatemeh Zeraati Malihe Araghchian Mohammad Hadi Farjoo

BACKGROUND Combining different analgesic drugs for improvement of drug efficacy is a recommended strategy intended to achieve the optimal therapeutic effects. OBJECTIVES The purpose of the present study was to assess the nature of the interaction between ascorbic acid and two analgesic drugs, morphine and tramadol. MATERIALS AND METHODS The analgesic activity was assessed by the acetic acid...

Journal: :The Biochemical journal 1994
C Bou-Hanna B Berthon L Combettes M Claret C L Laboisse

The mechanisms of Ca(2+)-induced mucin secretion were examined in monolayers of the differentiated epithelial colon cell line C1.16E by combined measurements of free intracellular Ca2+ ([Ca2+]i) using a fluorescence indicator and mucous secretion using a specific and sensitive electrophoretic assay. Carbachol, a cholinergic agonist, induced an initial concentration-dependent [Ca2+]i peak increa...

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