The North Atlantic Oscillation (NAO) is one of the most prominent and recurrent patterns of atmospheric circulation variability. It dictates climate variability from the eastern seaboard of the United States to Siberia and from the Arctic to the subtropical Atlantic, especially during boreal winter, so variations in the NAO are important to society and for the environment. Understanding the pro...

Background High suicide rates in the Russian North are coupled with high alcohol consumption in the described populations. Objective To investigate the potential role of alcohol consumption on suicides in the Nenets Autonomous Okrug (NAO) in 2002-2012 and to compare this information with corresponding data from the neighboring Arkhangelsk Oblast (AO). Design Retrospective population-based morta...

The release of cytochrome c from the mitochondria to the cytosol is a critical step for downstream caspase-mediated apoptotic signal transduction in ischemia-reperfusion (I/R)-induced myocardial tissue injury. 10-N-nonyl acridine orange (NAO), a cardiolipin-specific dye, has been shown to inhibit Bid-mediated cytochrome c release from isolated mitochondria in vitro; however, the possible protec...

PNA is a nucleic acid analog with an achiral polyamide backbone consisting of N-(2-aminoethyl)glycine units (figure 1). The purine or pyrimidine bases are linked to the each unit via a methylene carbonyl linker (1-3) to target the complementary nucleic acid (4). PNA binds to complementary RNA or DNA in a parallel or antiparallel orientation following the Watson-Crick base-pairing rules (5-7). T...

The biological activity of a combined treatment of U251, U373 and T98G glioma cell lines with two anti-miR PNAs, directed against miR‑221 and miR‑222 and conjugated with an ocataarginine tail (R8-PNA-a221 and R8-PNA-a222) for efficient cellular delivery, was determined. Apoptosis was analyzed, and the effect of the combined treatment of glioma cells with either or both PNAs on the reversion of ...

Differentiation of most T lymphocytes occurs within the thymus and is characterized by variable expression of CD4/CD8 coreceptor molecules, increased surface density of T cell antigen receptor (TCR) alpha beta proteins, and decreased expression of glycan chains recognized by the galactose-specific lectin peanut agglutinin (PNA). Although appreciated for several decades that PNA agglutination is...

The assessment of wind energy potential is generally based on the analysis statistical distribution observed speed short time resolution. Record periods observational data used in practice at sites interest are often very short, ranging from a few months to years. Predictions such small record likely be biased as it recognized that subject important interannual variability and long-term trends....

[1] In this paper, by using a dynamic model with synoptic eddy and low-frequency flow (SELF) interaction, we show that the SELF feedback is of significant importance for the formation of the AO/NAO in both winter and summer. Although background storm activity is significantly weaker in summer than that in winter, the positive SELF feedback associated with the AO/NAO mode in summer can be as str...

[1] Observed multidecadal variability (30 yr runningmeans, trends, and moving standard deviations) of the North Atlantic Oscillation (NAO) during the instrumental record is compared to that simulated by two different coupled general circulation models in extended-range control experiments. Simulated NAO exhibits strong low frequency fluctuations, even on multi-centennial time scale. Observed mu...

  Background & Objectives: Antisense peptide nucleic acids (PNA) that target growth essential genes show potent bactericidal properties without cell lysis. We considered the possibility that whether PNA treatment influence the bacteria total nucleic acids content and apply approach to develop a new delivery system to Dendritic cells (DCs). DCs are the most potent antigen presenting cells in th...