Dietary intake of bioactive phytochemicals including the cruciferous vegetable derivative phenethyl isothiocyanate (PEITC) can reduce risk of human cancers, but possible epigenetic mechanisms of these effects are yet unknown. We therefore sought to identify the molecular basis of PEITC-mediated epigenetic tumor restriction. Colon cancer cells treated with low-dose PEITC for >1 month exhibited s...

heterochromatic-like structures, including deacetyla-tion and methylation of histone tails (Francis and Kings-ton, 2001). Of the two distinct complexes formed by the PcG proteins, the ESC-E(Z) complex associates with Summary histone deacetylases and the SET domain of E(Z) possesses H3 specific methyltransferase activity, while the Epigenetic silencing of Hox cluster genes by Polycomb group (PcG...

The role of rat organic anion transporter 3 (rOat3; Slc22a8) in the efflux transport at the blood-brain barrier (BBB) was characterized. The expression of rOat1, rOat2, and rOat3 in the brain capillary endothelial cells (BCEC) was examined using reverse transcription-polymerase chain reaction analysis, which showed that there was no expression of rOat1 or rOat2, but moderate expression of rOat3...

PURPOSE To identify deleterious mutations in the latent transforming growth factor-β-binding protein 2 (LTBP2) gene in sporadic patients with primary congenital glaucoma (PCG) from a Han Chinese population, which had been excluded for mutations in the CYP1B1 gene. METHODS In this retrospective case-control study, 36 coding exons and adjacent exon-intron boundaries of LTBP2 were amplified with...

BACKGROUND Primary Care Groups and Trusts (PCG/Ts) are responsible for improving the health of local populations, but there is little evidence of their strategic involvement in accident prevention. OBJECTIVE To determine the effect of providing information on local accidental injuries to PCG/Ts on the development of accident prevention strategies. METHODS The study is a randomized controlle...

Many plants respond to winter with epigenetic factors that gradually dampen repression of flowering so that they can flower in spring. The study of this process was important for the identification of the plant Polycomb group (PcG) of proteins and their role in the epigenetic control of plant gene expression. Fittingly, these studies continue to illuminate our understanding of PcG function. We ...

Procedural Content Generation (PCG) used to be a method to circumvent technical limitations; at the present time PCG serves to automate and leverage potential surpluses of computing power. In this paper, I describe and recreate relevant antecedents to methods of PCG in game design, in order to better understand their use in the past and present. My research methods straddle both critical readin...

Abstract. Mapping the distribution of plastic covered greenhouses (PCG) is essential for any attempts to manage these complex areas intensive agriculture. It therefore important understand how spectrum different PCG varies in order establish its unique absorption features and can be utilised mapping from remote sensing imagery. This paper presents an analysis surface reflectance values satellit...

Polycomb Group (PcG) proteins are best-known for maintaining repressive or active chromatin states that are passed on across multiple cell divisions, and thus sustain long-term memory of gene expression. PcG proteins engage different, partly geneand/or stage-specific, mechanisms to mediate spatiotemporal gene expression during central nervous system development. In the course of this, PcG prote...