OBJECTIVE Nigella sativa extract has been used in the Middle East as a traditional medicine for several complaints. We aimed to evaluate the biochemical, histopathological and hematologic changes in Toxocara canis-infected mice after treatment with Nigella sativa extract, albendazole or a combination of both. METHODS This comparative study was conducted between June and July 2008 at the Itarr...

Effects of Nigella sativa Allelochemical Substances on Growth-Inhibiting Flixweed Compared With Wheat (Triticum aestivum)

Nigella sativa (black seed) is an important medicinal herb. In many Arabian, Asian and African countries, black seed oil is used as a natural remedy for a wide range of diseases, including various allergies. The plant's mechanism of action is still largely unknown. Due to the lack of study data on its efficacy in allergies, four studies on the clinical efficacy of Nigella sativa in allergic dis...

BACKGROUND In previous studies, the relaxant, anticholinergic (functional antagonism) and antihistaminic effects of Nigella sativa have been demonstrated on guinea pig tracheal chains. To elucidate the other mechanisms responsible for the relaxant effect of this plant, its inhibitory effect on the calcium channel was examined in this study. RESULTS The inhibitory effects of both concentration...

Article history: Received on: 21/06/2016 Revised on: 12/07/2016 Accepted on: 28/07/2016 Available online: 30/08/2016 Even though whey protein complex derived from milk, is being touted as a functional food with a number of health benefits, so far its full mechanistic effect has not been deeply explicated, which is the target of this study. For this reason, we observed the 2 months protection in...

Nigella sativa, an established historical and religion-based remedy for a wide range of health problems, is a herbal medicine known to have antioxidant and neuroprotective effects. This present study investigated the effect of Nigella sativa oil (NSO) administration on the spatial memory performance (SMP) of male adult rats using eight-arm radial arm maze (RAM). Twelve Sprague Dawley rats (7-9 ...

objective: oxidative stress plays an important role in the etiology of diabetic complications. diabetes impairs hippocampus neurogenesis, synaptic plasticity, and learning. the aim of this study was to investigate the effects of hydroalcoholic extract of nigella sativa seed on oxidative stress in stz-induced diabetic rats' hippocampus. materials and methods: diabetes induced by 60 mg/kg st...

Six rare naturally occurring indazole-type alkaloids including two new compounds, 17-O-(β-d-glucopyranosyl)-4-O-methylnigellidine (1) and nigelanoid (2), and four known compounds (3-6) were isolated from a defatted extract of Nigella sativa (black cumin) seeds. 17-O-(β-d-Glucopyranosyl)-4-O-methylnigellidine (1) increased glucose consumption by liver hepatocytes (HepG2 cells) through activation...

in order to evaluation the effect of nigella sativa supplementation on performance, immune response and some of blood parameters, a total of 192 one day old ross 308 broilers were used in a completely randomize design with four treatments, four replicates and 12 observations in each replicate. treatments included the increasing levels of zero (control), 0.4, 0.8 and 1.2 percent nigella sativa. ...