Medullary thyroid carcinoma (MTC) is a rare tumour which frequently occurs in the context of the multiple endocrine neoplasia syndromes, where it coexists with other usually benign tumours. The clinical picture varies and distant metastases are frequently present at diagnosis. Calcitonin levels are elevated in the presence of metastatic disease. Two MTC cases are presented, which had elevated p...

Magnetic targeted carriers (MTC) are magnetically susceptible microparticles that can be physically targeted to a specific site. MTC were radiolabeled with (111)In using three different methods. Reaction parameters were investigated in order to optimize the final properties of the labeled MTC. The reaction parameters studied were chelation agent, chelation time, temperature, radiolabeling time,...

After ligand binding induces dimerization, the RET receptor tyrosine kinase activates multiple signal transduction pathways. Constitutively activating mutations and chromosomal rearrangements are the primary oncogenic event in a significant number of medullary thyroid cancers (MTC) and papillary thyroid cancers (PTC), respectively. When specific germline mutations in RET are identified early, p...

When building a complex pattern recognizer with high-dimensional input features, a number of selection uncertainties arise. Traditional approaches to resolving these uncertainties typically rely either on the researcher's intuition or performance evaluation on validation data, both of which result in poor generalization and robustness on test data. This paper describes a novel recognition techn...

Medullary thyroid carcinoma (MTC) is a neuroendocrine (NE) malignancy that frequently metastasizes and has limited treatments. We recently reported that ectopic expression of Notch-1 in human MTC cells suppresses growth. The objective of this study was to evaluate the ability of suberoyl bis-hydroxamic acid (SBHA) to modulate Notch-1 signaling in MTC cells. At baseline, no active Notch-1 protei...

Random access procedure is an access mechanism to radio resources in Long Term Evolution (LTE) mobile networks to handle a competition for radio resources of Machine Type Communication (MTC) devices. In the random access procedure, the MTC devices transmit a request for radio resources in the first available opportunity. The devices which select the same resource fail the access and need to com...

We consider temporal graphs with discrete time labels and investigate the size and the approximability of minimum temporally connected spanning subgraphs. We present a family of minimally connected temporal graphs with n vertices and Ω(n2) edges, thus resolving an open question of (Kempe, Kleinberg, Kumar, JCSS 64, 2002) about the existence of sparse temporal connectivity certificates. Next, we...

Exascale systems will bring significant challenges. This work attempts to addresses them through the Many-Task Computing (MTC) paradigm, by delivering data-aware job scheduling systems and fully asynchronous distributed architectures. MTC applications are structured as DAG graphs of tasks, with dependencies forming the edges. The asynchronous nature of MTC makes it more resilient than tradition...

Research on medullary thyroid carcinoma (MTC) over the last 55 years has led to a good understanding of the genetic defects and altered molecular pathways associated with its development. Currently, with the use of genetic testing, patients at high risk for MTC can be identified before the disease develops and offered prophylactic treatment. In cases of localized neck disease, surgery can be cu...

Many-Task Computing (MTC) aims to bridge the gap between HPC and HTC. MTC emphasizes running many computational tasks over a short period of time, where tasks can be either dependent or independent of one another. MTC has been well supported on Clouds, Grids, and Supercomputers on traditional computing architectures, but the abundance of hybrid large-scale systems using accelerators has motivat...