Diarrheal disease is one of the leading causes of worldwide morbidity and mortality, especially in children. It causes loss of body fluid, which may lead to severe dehydration, electrolyte imbalance, shock and even to death. The mortality rate from acute diarrhea has decreased over the last few decades. This decline, especially in developing countries is largely due to the implantation of the s...

Mouse colorectal cancer (CRC) models generated by orthotopic microinjection of human CRC cell lines reproduce the pattern of lymphatic, haematological and transcoelomic spread but generate low metastatic efficiency. Our aim was to develop a new strategy that could increase the metastatic efficiency of these models. We used subcutaneous implantation of the human CRC cell lines HCT116 or SW48 pri...

OBJECTIVE To explore whether aberrant transient chondrocyte behaviors occur in the joints of STR/Ort mice (which spontaneously develop osteoarthritis [OA]) and whether they are attributable to an endochondral growth defect. METHODS Knee joints from STR/Ort mice with advanced OA and age-matched CBA (control) mice were examined by Affymetrix microarray profiling, multiplex polymerase chain reac...

On November 13 and 14, 1996, a scientific symposium on oral rehydration therapy (ORT) was held at the Johns Hopkins University School of Hygiene and Public Health in Baltimore, MD. The purpose of the meeting was to review the current treatment practices for the treatment of this disease in the United States. The group noted that diarrhea resulted in 300 to 400 deaths per year among children, ap...

A study to determine the association between the use of oral rehydration therapy (ORT) by mothers who had children under five years old with diarrhea and their knowledge of diarrhea was conducted in 19 health centers and a hospital at Muang District, Samut Songkhram Province. It was found that in general there was significant association between the use of ORT and mother's knowledge of diarrhea...

In many settings, including venture capital …nancing, mergers and acquisitions, and lease competition, the structure of the contracts (debt versus equity) over which …rms compete di¤ers. Furthermore, the structure of the contract a¤ects the future incentives of the …rm to engage in value-creating activities by potentially diluting e¤ort or investment incentives. We study, both theoretically and...