نتایج جستجو برای: سم عصبی mptp

تعداد نتایج: 19772  

Journal: :Journal of neuropathology and experimental neurology 2006
Xi Jun He Hiroyuki Nakayama Mei Dong Hirofumi Yamauchi Masaki Ueno Koji Uetsuka Kunio Doi

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is commonly used to create animal models of Parkinson disease. There is conflicting evidence on the occurrence of apoptosis induced by MPTP in the mouse substantia nigra pars compacta. We demonstrated that a single acute injection of MPTP induced apoptosis in the subventricular zone (SVZ) and rostral migratory stream (RMS) in the adult C57BL/6...

Journal: :European journal of pharmacology 2009
Dingzhen Luo Quanbin Zhang Haomin Wang Yanqiu Cui Zuoli Sun Jian Yang Yan Zheng Jun Jia Fen Yu Xuan Wang Xiaomin Wang

Parkinson's disease is a neurodegenerative disorder of uncertain pathogenesis characterized by a loss of dopaminergic neurons in substantia nigra pars compacta, and can be modeled by the neurotoxin 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP). Oxidative stress may contribute to MPTP- and Parkinson's disease-related neurodegeneration. Fucoidan is a sulfated polysaccharide extracted fro...

2014
Chen Lu Jin Zhang Xiaopeng Shi Shan Miao Linlin Bi Song Zhang Qian Yang Xuanxuan Zhou Meng Zhang Yanhua Xie Qing Miao Siwang Wang

Parkinson's disease (PD) is the second most prevalent progressive neurodegenerative disease. Although several hypotheses have been proposed to explain the pathogenesis of PD, apoptotic cell death and oxidative stress are the most prevalent mechanisms. Tetramethylpyrazine (TMP) is a biological component that has been extracted from Ligusticum wallichii Franchat (ChuanXiong), which exhibits anti-...

2012
Kang-Woo Lee Xin Zhao Joo-Young Im Hilary Grosso Won Hee Jang Teresa W. Chan Patricia K. Sonsalla Dwight C. German Hidenori Ichijo Eunsung Junn M. Maral Mouradian

Apoptosis signal-regulating kinase 1 (ASK1), a member of the mitogen-activated protein kinase 3 family, is activated by oxidative stress. The death-signaling pathway mediated by ASK1 is inhibited by DJ-1, which is linked to recessively inherited Parkinson's disease (PD). Considering that DJ-1 deficiency exacerbates the toxicity of the mitochondrial complex I inhibitor 1-methyl-4-phenyl-1,2,3,6-...

Journal: :Biological & pharmaceutical bulletin 2004
Bin Liu Jun Xia Xie Dewi Kenneth Rowlands Yu Lin Gou Ching Cheong Leung Yiu Wa Chung Hsiao Chang Chan

Neuroprotective effects of estrogen and estrogen-like chemicals on neurodegenerative diseases, especially Parkinson's disease, have been well established. In the present study, we compared the effects of Bak Foong Pill (BFP), a well-known gynaecological tonic in China, and 17beta-estradiol, on dopamine transporter (DAT) and tyrosine hydroxylase (TH) gene expression patterns in ovariectomized, 1...

2016
Emily Filichia Barry Hoffer Xin Qi Yu Luo

Accumulating evidence suggest mitochondria-mediated pathways play an important role in dopaminergic neuronal cell death in Parkinson's disease (PD). Drp1, a key regulator of mitochondrial fission, has been shown to be activated and translocated to mitochondria under stress, leading to excessive mitochondria fission and dopaminergic neuronal death in vitro. However, whether Drp1 inhibition can l...

2015
SEKAR SATHIYA CHIDAMBARAM SARAVANA BABU

Objective: Telmisartan (TEL), an angiotensin type 1 receptor blocker, exerts neuroprotection in MPTP induced Parkinson’s disease. The present study was aimed to investigate its effects on oxidative stress markers–inducible nitric oxide synthase (iNOS), nitric oxide (NO) and reduced glutathione (GSH) content in C57BL/6J mice brain. Methods: Young healthy male C57BL/6J mice were injected intraper...

2002
Martyn T. Smith

Oxidative stress and covalent binding have been proposed as possible mechanisms involved in the cytotoxic effects of the parkinsonism-causing compound l-methyl-4-phenyl-I,2,3,6-tetrahydzopyridine (MPTP). However, the toxicity induced by MPTP in isolated fat hepatocytes seems to be relatively independent of oxygen ~adical-induced oxidative stress. Here we demonstrate that MPTP cytotoxicity is no...

Journal: :The Journal of biological chemistry 1989
S Ottoboni P Caldera A Trevor N Castagnoli

Kinetic deuterium isotope effects for the noncompetitive, intermolecular monoamine oxidase B-catalyzed oxidation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to the corresponding 1-methyl-4-phenyl-2,3-dihydropyridinium species MPDP+ were found to be 3.55 on Vmax and 8.01 on Vmax/Km with MPTP-6,6-d2 as the deuterated substrate. Similar values were obtained with MPTP-2,2,6-d4 and MPTP-C...

2014
Caroline Santos Capitelli Carolina Salomão Lopes Angélica Cristina Alves Janaína Barbiero Lucas Felipe Oliveira Valdo José Dias da Silva Maria Aparecida Barbato Frazão Vital

The 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) animal model is a useful tool to study Parkinson's disease (PD) and was used in the present study to investigate the potential beneficial as well as deleterious effects of systemic bone-marrow mononuclear cell (BMMC) or mesenchymal stem cell (BM-MSC) transplantation. MPTP administration resulted in a breakdown of the blood-brain barrier an...

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