نتایج جستجو برای: سلول های nb4

تعداد نتایج: 480512  

1999
Masaaki Shiohara Marcia I. Dawson Peter D. Hobbs Nobukuni Sawai Tsukasa Higuchi Kenichi Koike Atsushi Komiyama Phillip Koeffler

Retinoids such as all-trans-retinoic acid (ATRA) and 9-cisretinoic acid (9-cis-RA) have an important role in many aspects of proliferation and differentiation of hematopoietic cells. They exert their effects by binding to retinoic acid receptors (RARs) and/or retinoid X receptors (RXRs). We studied the effects of novel retinoids on proliferation and differentiation of HL-60 and NB4 myeloid leuk...

Journal: :Blood 2002
Qi Zhu Ji-Wang Zhang Hai-Qing Zhu Yu-Lei Shen Maria Flexor Pei-Ming Jia Yun Yu Xun Cai Samuel Waxman Michel Lanotte Sai-Juan Chen Zhu Chen Jian-Hua Tong

Acute promyelocytic leukemia (APL) is characterized by the specific chromosome translocation t(15;17) with promyelocytic leukemia-retinoic acid receptor-alpha (PML-RARA) fusion gene and the ability to undergo terminal differentiation as an effect of all-trans retinoic acid (ATRA). Recently, arsenic trioxide (As(2)O(3)) has been identified as an alternative therapy in patients with both ATRA-sen...

ژورنال: کومش 2020

Introduction: Given to the fact that the high toxicity and side effects of chemotherapeutic drugs have limited their clinical use, it is not surprising that novel therapeutic drugs with less toxicity and more efficacy have entered into the novel protocols. Relatively, Melatonin, a main product of pineal gland, not only plays a key role in the regulation of circadian rhythm, but also exerts anti...

Journal: :Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1994
S Matikainen H Tapiovaara A Vaheri M Hurme

We have examined the expression of the interleukin 1 beta (IL-1 beta) gene during the granulocytic differentiation of two promyeloid leukemia cell lines, HL-60 and NB4. HL-60 is known to differentiate along the granulocytic pathway after treatment with 13-trans-retinoic acid (13-trans-RA), whereas treatment with phorbol myristate acetate (PMA) leads to development of mature macrophages. NB4 cel...

Journal: :Blood 1996
J V Raelson C Nervi A Rosenauer L Benedetti Y Monczak M Pearson P G Pelicci W H Miller

Acute promyelocytic leukemia (APL) is characterized by the translocation, t(15;17) and the expression of a PML/RAR alpha fusion protein that is diagnostic of the disease. There is evidence that PML/RAR alpha protein acts as a dominant negative inhibitor of normal retinoid receptor function and myeloid differentiation. We now show that the PML/RAR alpha fusion product is directly downregulated i...

چکیده سابقه و هدف پیشگیری، درمان و کنترل سرطان با استفاده از مواد طبیعی در حال حاضر به عنوان یک استراتژی امیدوارکننده در نظر گرفته شده است. در این خصوص، کافئین که یک آلکالوئید پورینی موجود در گیاهان مختلف از جمله قهوه، کاکائو، کولا و چای می‌باشد، به دلیل مهار چند منظوره سرطان از جمله لوسمی‌ها به تازگی توجه زیادی به خود جلب کرده است. مواد و روش‌ها در یک مطالعه تجربی به منظور بررسی اثر کافئین د...

ژورنال: پیاورد سلامت 2010
بشاش, داوود, علی مقدم, کامران, عین اللهی, ناهید, غفاری, سید حمیداله, قوام زاده, اردشیر, مردانی ولندانی, هاجر, میرزایی خلیل آبادی, روح الله,

Background and Aim: APL is a Prevalent leukemia that Approximately included 5-10% of patients with acute myeloblastic leukemia. ATRA and recently arsenic is used for treatment. ATRA leadsto resistance to treatment and arsenic is toxic in high doses.AZT induce cell death in different ways. The purpose of this study was Assessment of effect of AZT, a telomerase inhibitor, on NB4 cell line (APL ce...

Journal: :Cancer research 2001
N Idres G Benoît M A Flexor M Lanotte G G Chabot

The metabolism of all-trans retinoic acid (ATRA) has been reported to be partly responsible for the in vivo resistance to ATRA seen in the treatment of human acute promyelocytic leukemia (APL). However, ATRA metabolism appears to be involved in the growth inhibition of several cancer cell lines in vitro. The purpose of this study was to evaluate the in vitro activity of the principal metabolite...

Journal: :Blood 1994
A Khanna-Gupta K Kolibaba T A Zibello N Berliner

NB4 is an acute promyelocytic leukemia cell line that has been shown to be inducible to terminal neutrophil maturation with all-trans retinoic acid (ATRA). HL60 cells are differentially inducible with 12-O-tetradecanoylphorbol-13-acetate (TPA) or dimethyl sulfoxide (DMSO) to monocytes or granulocytes, respectively. HL60 cells induced with DMSO undergo defective neutrophil maturation, manifested...

Journal: :Journal of biochemistry and molecular biology 2006
Mohammad Amin Moosavi Razieh Yazdanparast Abbas Lotfi

Recently, we have reported that 3-hydrogenkwadaphnin (3-HK), a diterpene ester isolated from Dendrostellera lessertii (Thymealeaceae), is very effective against leukemia cell lines without any detectable effects on normal cells (Moosavi et al., 2005b). In this study, we report that 3-HK induces G1 cell-cycle arrest, differentiation and apoptosis in APL NB4 cell line. Indeed, the drug between 24...

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