نتایج جستجو برای: سطح سرمی hcg

تعداد نتایج: 159157  

Journal: :Reproductive Biology and Endocrinology : RB&E 2009
Laurence A Cole

Human chorionic gonadotropin (hCG) is a glycoprotein hormone comprising 2 subunits, alpha and beta joined non covalently. While similar in structure to luteinizing hormone (LH), hCG exists in multiple hormonal and non-endocrine agents, rather than as a single molecule like LH and the other glycoprotein hormones. These are regular hCG, hyperglycosylated hCG and the free beta-subunit of hyperglyc...

Journal: : 2022

Aim. To analyse the levels of serum beta-human chorionic gonadotropin (β-hCG) and pregnancy-associated plasma protein A (PAPP-A) in pregnant women without fetal chromosomal abnormalities with trisomy 21 (Down syndrome) or 18 (Edwards syndrome). Materials Methods. We performed a retrospective analysis biochemical parameters 1214 who had previously undergone karyotyping as part prenatal postnatal...

Journal: :Photonics 2023

Vertical-cavity surface-emitting lasers (VCSELs) have been widely used in consumer electronics, light detection and ranging, optical interconnects, atomic sensors, so on. In this paper, a VCSEL with the surface metastructure like one-dimensional high-contrast grating (HCG), based on HCG-DBR vertical cavity, was first designed fabricated. The polarization characteristic of HCG-VCSEL were experim...

2012
Laurence A Cole

BACKGROUND hCG is a wonder. Firstly, because hCG is such an extreme molecule. hCG is the most acidic glycoprotein containing the highest proportion of sugars. Secondly, hCG exists in 5 common forms. Finally, it has so many functions ranging from control of human pregnancy to human cancer. This review examines these molecules in detail. CONTENT These 5 molecules, hCG, sulfated hCG, hyperglycos...

2017
Hideyuki Ikenaga Yudai Tanaka Masahide Shiotani Daniela Rogoff Shin Shimizu Osamu Ishihara Yoshiaki Sato Yoshiharu Morimoto Aisaku Fukuda Kohzo Aisaka Koji Yoshida Naoki Hayashi Hirotsugu Oku Yuji Abe Atsushi Haruki Motoharu Ishikawa Takeshi Kuramoto

Aim Outside of Japan, recombinant-human chorionic gonadotropin (r-hCG) is widely used for the induction of final follicular maturation and early luteinization in women undergoing ovulation induction; whereas in Japan, urine-derived hCG (u-hCG) is predominantly used. The primary objective of this study was to demonstrate the non-inferiority of r-hCG to u-hCG for ovulation induction, as assessed ...

2018
Wilhelmina Bagchus Peter Wolna Wolfgang Uhl

Purpose Recombinant hCG (r-hCG) was approved in Japan in 2016. As a prerequisite for a Phase III study in Japan related to this approval, the pharmacokinetic (PK) profile of r-hCG was investigated. Methods An open-label, partly randomized, single-center, single-dose, group-comparison, Phase I PK-bridging study was done that compared a single 250 μg dose of r-hCG with a single 5000 IU dose of ...

Journal: :Clinical chemistry 1997
L A Cole

Multiple hCG-related molecules are present in pregnancy serum and urine samples. These include non-nicked hCG (the hormone), nicked hCG, hyper- and hypoglycosylated hCG, hCG missing the C-terminal extension, free alpha-subunit, large free alpha-subunit, free beta-subunit, nicked free beta-subunit, and beta-core fragment. Over 100 immunoassays are sold for quantifying hCG-related molecules in se...

Journal: :The Journal of clinical investigation 1985
S Amr C Rosa S Birken R Canfield B Nisula

Previous investigations of patients with gestational trophoblastic neoplasia have shown that their urines often contain carboxyterminal peptide (CTP) fragments of the choriogonadotropin (hCG) beta-subunit as well as forms of hCG deficient in sialic acid. In order to determine whether beta-CTP fragments are among the urinary products of the peripheral degradation of desialylated hCG (as-hCG), us...

Journal: :Clinical chemistry 2001
L A Cole S Shahabi S A Butler H Mitchell E S Newlands H R Behrman H L Verrill

BACKGROUND Patients with trophoblastic diseases produce ordinary and irregular forms of human chorionic gonadotropin (hCG; e.g., nicked hCG, hCG missing the beta-subunit C-terminal segment, hyperglycosylated hCG, and free beta subunit) that are recognized to differing extents by automated immunometric hCG (or hCG beta) assays. This has led to low or false-negative results and misdiagnosis of pe...

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