The heavy chain (HC) of the neonatal Fc receptor (FcRn) for IgG is non-convalently associated with beta(2)-microglobulin (beta(2)m). In beta(2)m(-/-) mice, FcRn functions are greatly impaired. We sought to determine how FcRn HC, particularly its structure and biogenesis, is affected by the absence of beta(2)m. Human FcRn HC, expressed from the beta(2)m-null cell line FO-1(FcRn), was present as ...

It is important to note, however, that it is expected that subcutaneous home HC would be offered to patients with AI who are unlikely or unwilling to use i.m. HC, in an effort to prevent hypotension before they can access more definitive medical care. Indeed, an emergency physician should assess all patients who have received a subcutaneous injection at home to determine the need for ongoing HC...

An as-synthesised hollow carbon nanoparticle (HC-NP) sample has been proved to be a relatively complex mixture, and its complexity can be reduced significantly by high-performance liquid chromatography. An unprecedented reduction in such complexity can reveal fractions of HC-NP with unique luminescence properties. While the UV-vis absorption profile for the HC-NP mixture is featureless, the HC-...

INTRODUCTION Our aim was to investigate the correlations between patterns of head growth and intellectual disability among distinct aetiological presentations of microcephaly. PATIENTS AND METHODS 3,269 head circumference (HC) charts of patients from a tertiary neuropediatric unit were reviewed and 136 microcephalic participants selected. Using the Z-scores of registered HC measurements we de...

OBJECTIVE To examine the association between hormonal contraception (HC) and bacterial vaginosis (BV) by systematic review and meta-analysis. METHODS Medline, Web of Science and Embase databases were searched to 24/1/13 and duplicate references removed. Inclusion criteria 1) >20 BV cases; 2) accepted BV diagnostic method; 3) measure of HC-use either as combined oestrogen-progesterone HC (comb...

AIM We investigated the effects of a calorie-restricted low-carbohydrate diet on glucose and lipid metabolism, and body fat distribution, especially on the secretion of leptin and lipoprotein lipase from adipose tissue in Otsuka Long Evans Tokushima Fatty (OLETF) rats. METHODS Forty-three week-old male OLETF rats were randomized into three groups (n=6 per group): the HC group (HC) was fed a d...

The degree of acute hepatic failure after severe trauma and sepsis is related to the extent of hepatocyte (HC) damage and cell death resulting from either necrosis or apoptosis. We have previously demonstrated that tumor necrosis factor-α (TNF-α) and lipopolysaccharide (LPS) can directly lead to HC necrosis, but not apoptosis. To date, the reactive oxygen intermediates (ROI) and nitric oxide (N...

As the amount of sequencing efforts and genomic data volume continue to increase at an accelerated rate, phylogenetic analysis provides an evolutionary context for understanding and interpreting this growing set of complex data. We introduce a novel quartet based method for inferring molecular based phylogeny called hypercleaning* (HC). The HC method is based on the hypercleaning (HC) technique...

SUMMARY In this paper, we propose a new modulation named parallel combinatory/high compaction multi-carrier modulation (PC/HC-MCM) using the techniques of parallel combinatory orthogonal frequency division multiplexing (PC-OFDM) and high compaction multi-carrier modulation (HC-MCM). Two types of PC/HC-MCM systems, which are named as modulated PC/HC-MCM system and (unmodulated) PC/HC-MCM system ...