هدف: این پژوهش با هدف ارائه مدل چالش‌های پرورش کودکان کم‌شنوای پیش‌دبستانی از دیدگاه مادران و متخصصان بر اساس نظریه داده‌بنیاد انجام ‌شده است. روش: نمونه 15 مادر کودک کم‌شنوا 4 تا 6 ساله انجمن والدین شهر تهران 5 متخصص حوزه ناشنوا بودند که در سال 1400 استفاده روش نمونه‌گیری هدفمند انتخاب شدند. چالش ­های طریق مصاحبه نیمه ساختاریافته عمیق رسیدن به اشباع نظری جمع‌آوری کدگذاری (کدگذاری باز، محوری ان...

E-RAS is a member of the RAS family specifically expressed in embryonic stem cells, gastric tumors, and hepatic stellate cells. Unlike classical RAS isoforms (H-, N-, and K-RAS4B), E-RAS has, in addition to striking and remarkable sequence deviations, an extended 38-amino acid-long unique N-terminal region with still unknown functions. We investigated the molecular mechanism of E-RAS regulation...

Despite the fact that there are wastewater treatment plants (WWTPs) currently operational across Iran and great advances have been made in this area, there are still problems in the design, construction, and operation of WWTPs with large nonlinear systems, varying flow rates, and pollution charges. The objective of this study was to investigate the effect of operating parameters including the r...

Abstract :  Reovirus (respiratory enteric orphan virus), a naturally occurring benign human pathogen, has an inherent ability to target transformed and cancerous cells and cause their lysis, while leaving non-transformed cells relatively unaffected.  The efficiency of this innate oncolytic activity of reovirus correlates with expression of the ras oncogene.  Cells expressing ac...

1. Abstract 2. Introduction 2.1. Mutated proteins can induce malignant transformation 2.2. Mutant ras-p21 Protein Is a Major Cause of Cancer 2.3. ras-induced signal transduction pathways 2.4. Direct interactions between ras-p21 and target proteins depends largely on two of its domains 2.5. How amino acid substitutions in ras-p21 can induce it to become oncogenic 3. Methods 3.1. Computational me...

One of the main concerns of scholars working in the field of EAP over the last 2decades has been raising the awareness of EAP students and publishers of genreconventions in academic journals. In line with the above concern, many studies haveaimed at exploring the general characteristics of research articles (RAs) in the field.Among these features, it seems that the generic moves and textuality ...

R-Ras has a high degree of sequence homology to Ras and to other members of the Ras subfamily including Rap, TC21 and M-Ras. Activated versions of Ras and TC21 are highly transforming in a variety of cell lines and mutated forms of both proteins have been found in human tumours. R-Ras interacts with many of the same proteins as Ras and TC21, including c-Raf1, and can induce transformed foci, al...

هدف: پژوهش حاضر با هدف تحلیل و بررسی پیامدهای شبکه‌سازی سیاسی در نظام سیاست‌گذاری سازمان‌های دولتی استان لرستان انجام پذیرفت.طراحی/ روش‌­شناسی/ رویکرد : دارای رویکردی آمیخته است که از نظر هدف، کاربردی حیث ماهیت روش، توصیفی پیمایشی است. مشارکت‌کنندگان را مدیران تشکیل می­‌دهند استفاده اصل کفایت نظری روش نمونه­‌گیری هدفمند 16 نفر آنان به عنوان اعضای نمونه انتخاب شدند. بخش کیفی برای گردآوری داده مص...