UAV laser scanning (ULS) has the potential to support forest operations since it provides high-density data with flexible operational conditions. This study examined use of ULS systems estimate several tree attributes from an uneven-aged northern hardwood stand. We investigated: (1) transferability raster-based and bottom-up point cloud-based individual detection (ITD) algorithms data; (2) auto...

Bilateral cochlear implant (BiCI) users have shown variability in interaural time difference (ITD) sensitivity at different places along the cochlea. This paper investigates perception of multi-electrode binaural stimulation to determine if auditory object formation (AOF) and lateralization are affected by variability in ITD sensitivity when a complex sound is encoded with multi-channel process...

In this issue of Blood, Dany et al demonstrate a critical role of the ceramideregulated signaling pathway in inducing mitophagy to cause cell death and overcome drug resistance of acute myeloid leukemia (AML) cells carrying internal tandem duplication (ITD) of the Fms-like tyrosine kinase 3 (FLT3) gene. Inhibition of FLT3-ITD signaling through altering ceramide-involved lipid metabolism provide...

The combined selectivity for amplitude modulation frequency (AMF) and interaural time difference (ITD) was investigated for single units in the auditory midbrain of the grassfrog. Stimuli were presented by means of a closed sound system. A large number of units was found to be selective for AMF (95%) or ITD (85%) and mostly, these selectivities were intricately coupled. At zero ITD most units s...

The NUP98-NSD1 fusion, product of the t(5;11)(q35;p15.5) chromosomal translocation, is one of the most prevalent genetic alterations in cytogenetically normal pediatric acute myeloid leukemias and is associated with poor prognosis. Co-existence of an FLT3-ITD activating mutation has been found in more than 70% of NUP98-NSD1-positive patients. To address functional synergism, we determined the t...

Acute myeloid leukemia (AML) with normal cytogenetics represents approximately 40% to 50% of de novo AML. This heterogeneous AML subgroup constitutes the single largest cytogenetic group with an intermediate prognosis. Previous studies have suggested that the Fms-like tyrosine kinase-3 internal tandem duplication (FLT3/ITD) mutation-positive de novo AML may represent a distinctive subgroup of A...

Activating mutations of the class III receptor tyrosine kinase FLT3 are the most frequent molecular aberration in acute myeloid leukemia (AML). Mutant FLT3 accelerates proliferation, suppresses apoptosis, and correlates with poor prognosis. Therefore, it is a promising therapeutic target. Here, we show that RNA interference against FLT3 with an internal tandem duplication (FLT3-ITD) potentiates...

Background and Purpose—Stroke and heart disease are the most serious complications of diabetes accounting for 65% of mortality among diabetics. Although intensive insulin therapy has significantly improved the prognosis of diabetes and its complications, it is associated with an elevated risk of recurrent hypoglycemia (RH). We tested the hypothesis that RH exacerbates cerebral ischemic damage i...

Targeting constitutively activated FMS-like tyrosine kinase 3 [(FLT3); FLT3-ITD] with tyrosine kinase inhibitor (TKI) in acute myeloid leukemia (AML) leads to clearance of blasts in the periphery but not in the bone marrow, suggesting a protective effect of the marrow niche on leukemic stem cells. In this study, we examined the effect of stromal niche cells on CD34(+) progenitors from patients ...

The barn owl's optic tectum contains a map of auditory space that is based, in part, on a map of interaural time difference (ITD). Previous studies have shown that this ITD map is shaped by auditory experience. In this study, we investigated whether the plasticity responsible for experience-induced changes in ITD tuning in the tectum occurs within the tectum itself or at an earlier stage in the...