INTRODUCTION Restless legs syndrome (RLS) is a prevalent sleep disorder affecting quality of life and is often comorbid with other neurological diseases, including peripheral neuropathy. The mechanisms related to RLS symptoms remain unclear, and treatment options are often aimed at symptom relief rather than etiology. RLS may present in distinct phenotypes often described as "primary" vs. "seco...

OBJECTIVES Restless legs syndrome (RLS) occurs in polyneuropathy with small fiber involvement, possibly as a peculiar form of neuropathic pain; however, the relationship between pain and RLS has been poorly investigated in polyneuropathy. DESIGN, SETTING, AND PATIENTS We evaluated retrospectively the occurrence of RLS in 102 consecutive patients with polyneuropathy manifesting with neuropathi...

Reduced brain iron is strongly associated with restless legs syndrome (RLS). Oral iron supplements are commonly recommended for RLS but are largely ineffective due to poor absorption and poor tolerability at required doses. Intravenous iron dextran has been shown to increase brain iron content. Surprisingly only a few reports have ever presented data on the clinical effect of high dose intraven...

A variation in right atrial and pulmonary arterial pressure might result in a shunt dynamic across a patent foramen ovale (PFO). In the present study we tested if peak exercise facilitates a restoration of right to left shunt (RLS) in stroke patients who demonstrated a functional PFO closure (no evidence of RLS across an initially demonstrated PFO). In stroke patients with PFO demonstrating a f...

This thesis introduces analysis tools for improving the current state of the art of heuristics for the Maximum Clique (MC) problem. The analysis focusses on algorithmic building blocks, on their contribution in solving hard instances of the MC problem, and on the development of new tools for the visualisation of search landscapes. As a result of the analysis on the algorithmic building blocks, ...

restless leg syndrome (rls) is a common cause of painful legs. the leg pain of restless leg syndrome typically eases with motion of the legs and becomes more noticeable at rest. stress or emotional upset can make symptoms worse. the purpose of the present study was to examine the relationship of emotional disturbance and quality of life to the severity of rls. using a descriptive-correlational ...

conclusions pregnancies complicated by rls are at increased risk for preterm birth. the improved sleep health of pregnant women could decrease pregnancy complications. results rls complicated 43.7 percent of pregnancies. sleepiness (ess score > 8) was reported in 36.4% of the subjects with preterm birth and 35.9% of the term group. no significant correlation was found between the ess score and ...

The symptoms of restless legs syndrome (RLS) are associated with reductions in patients' quality of life (QoL) and mental heath. Sleep disturbance, which is often the most troublesome symptom of RLS, may have a negative impact on patients' daytime cognitive abilities. Research has established a relationship between the symptoms of RLS and mood symptoms, but causality is unclear. Some studies ha...

BACKGROUND Restless legs syndrome (RLS), a common sensorimotor disorder, has a wide range of severity from merely annoying to affecting sleep and quality of life severely enough to warrant medical treatment. Previous epidemiological studies, however, have failed to determine the prevalence of those with clinically significant RLS symptoms and to examine the life effects and medical experiences ...

UNLABELLED RLSOBJECTIVES: To evaluate the humanistic and economic burden of a restless legs syndrome (RLS) diagnosis with regard to health-related quality of life, work productivity loss, healthcare resource use, and direct and indirect costs. STUDY DESIGN Self-reported data came from the 2012 National Health and Wellness Survey (NHWS), a large, annual, nationally representative cross-section...