BACKGROUND Paraplegia is a serious complication of operations on the thoracic and thoracoabdominal aorta. To investigate the mechanism by which motor neurons are damaged during these operations, we have reported a rabbit model of spinal cord ischemia. We also tested whether a free radical scavenger MCI-186 that is useful for treating ischemic damage in the brain can protect against ischemic spi...

BACKGROUND AND OBJECTIVE Curcumin, a natural compound, is derived from the rthizom of Curcuma longa. In vitro and in vivo preclinical studies have shown its anti-inflammatory, antioxidant, anticancer activities and so on. miR-186*, which was found by microarray technology, was highly expressed in lung carcinoma cells A549/DDP. The aim of this study is to illustrate whether Curcumin could promot...

Lung cancer is one of the leading causes of cancer-related death worldwide. Curcumin has been reported to have an antitumor effect by inducing apoptosis and suppressing growth of tumor cells. However, the mechanism by which curcumin exerts its anti-cancer effect needs further research. The purpose of the present study was to identify a miRNA-mediated mechanism which plays a role in the anti-can...

The mitochondrial respiratory activities and energy metabolism in the fetal rat brain were measured at the end of 30 minutes of intrauterine ischemia and after 2 and 4 hours of recirculation. The transient ischemia was associated with a delayed deterioration of cellular bioenergetic state and mitochondrial activities. The deterioration was not prevented by a free radical scavenger, 3-methyl-1-p...

BACKGROUND/AIMS Long non-coding RNAs (lncRNAs) are key players in the development and progression of human cancers. The lncRNA XIST (X-inactive specific transcript) has been shown to be upregulated in human non-small cell lung cancer (NSCLC); however, its role and molecular mechanisms in NSCLC cell progression remain unclear. METHODS qRT-PCR was conducted to assess the expression of XIST and ...

Receptor tyrosine kinases (RTKs), in response to their growth factor ligands, phosphorylate and activate downstream signals important for physiological development and pathological transformation. Increased expression, activating mutations and rearrangement fusions of RTKs lead to cancer, inflammation, pain, neurodegenerative diseases, and other disorders. Activation or over-expression of ALK, ...

PurposeThe purpose of this study was to report demographic trends in terms ethnicity/race and gender among the membership leadership positions Arthroscopy Association North America (AANA) American Orthopaedic Society Sports Medicine (AOSSM). Over years both AANA AOSSM will increase diversity through their committee positions.MethodsAANA were reviewed for 2010, 2015, 2020. Race/ethnicity divided...

ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Chodkiewicz J, Morawska K, Łukowska K. Research into alcohol-dependent persons in treatment during the COVID-19 pandemic. Part one – mental health of patients. Alcoholism and Drug Addiction/Alkoholizm i Narkomania. 2022;35(3):171-186. doi:10.5114/ain.2022.125278. APA Chodkiewicz, J., Morawska, K., & Łukowska, (202...