Argyrophilic nucleolar organizer region (AgNOR) counts in cytologic and histologic lymph node samples from healthy dogs and dogs with lymphoma were compared. Control samples were taken from 10 Beagle dogs (six female and four male dogs, 1.5-2 years), and lymphoma samples were taken from 16 dogs. Cytologic samples were obtained by fine-needle aspiration and impression and histologic samples by e...

Settings. Despite the limited diagnostic utility of AgNORs (argyrophilic nucleolar organiser region-associated proteins) for individual breast lesions, AgNOR analysis bears a significant potential for characterizing cell proliferative activity of breast lesions. Methodology. The present study investigated the relationship between mean AgNORs count and immunohistochemical expression of ER, PR, H...

Objectives: Assessment of the cell proliferation rate in tissues can be one of the markers for impending malignancy in precancers. The state of activation and the proliferation activity of the cells can be assessed by the frequency of silver stained Nucleolar Organiser regions (AgNOR) within the nuclei which is significantly higher in malignant cells. The present study was carried out to analyz...

Background: Nucleolar organizing regions (NORs) are associated with proliferative activity and represents as a diagnostic aid in several neoplastic entities. Objective: The purpose of this study was to determine and compare the AgNOR (Silver binding nucleolar organizing region) count in healthy oral mucosa, oral leukoplakia and oral squamous cell carcinoma (OSCC). Methods: The biopsied tissue s...

After the pioneering work by Ploton et al. [1] silver staining of nucleolar organizer regions (AgNOR) has been introduced into tumour pathology as a proliferation marker which is closely related to the rapidity of cell cycle [2]. Owing to wet autoclave pretreatment introduced by Öfner et al. [3] AgNOR analysis has now widely been standardized in tissue sections [4]. In cytological specimens, ho...