نتایج جستجو برای: رده سلولی ht 29
تعداد نتایج: 172094 فیلتر نتایج به سال:
Organisms of the Mycobacterium avium complex (MAC) cause disseminated disease in patients with AIDS, and evidence points to the gastrointestinal tract as the major route of infection. Since MAC can bind to and invade intestinal mucosal cells, we examined whether subinhibitory concentrations of antibiotics which have anti-MAC activity in vitro affect the interaction between MAC and HT-29 intesti...
BACKGROUND An increasing number of cyclic dipeptides (CDPs), particularly those containing proline, have been shown to exhibit important biological activity. MATERIALS AND METHODS We investigated the potential of seven proline-based CDPs to inhibit cancer cell growth in HT-29, HeLa and MCF-7 cell lines. We also tested whether any of the CDPs were able to induce apoptosis in HT-29 cells. RES...
AKT is often hyper-activated in human colorectal cancers (CRC). This current study evaluated the potential anti-CRC activity by AT7867, a novel AKT and p70S6K1 (S6K1) dual inhibitor. We showed that AT7867 inhibited survival and proliferation of established (HT-29, HCT116 and DLD-1 lines) and primary human CRC cells. Meanwhile, it provoked caspase-dependent apoptosis in the CRC cells. Molecularl...
Widdrol, a natural sesquiterpene present in Juniperus sp., has been shown to exert anticancer and antifungal effects. Emerging evidence has suggested that AMP-activated protein kinase (AMPK), which functions as a cellular energy sensor, is a potential therapeutic target for human cancers. In this study, we found that AMPK mediates the anticancer e...
Background and Aim: Blastocystis sp., is one of the most common intestinal protozoan parasites found in both human and animal fecal samples. The pathogenicity and cytopathic effects of subtypes ST1-3 and 6 of Blastocystis sp., on gastrointestinal cell line are not clear. This study aimed to investigated intra-subtype variations on the apoptosis and cytopathic effects on HT-29 cell line in 2019,...
هدف: هدف از این تحقیق تاثیر پاراسپورین باسیلوس تورنجینسیس بر روی رده سلولی سرطان سینه موش در شرایط آزمایشگاهی بود. مواد و روشها: جداسازی توکسین کریستالی از ایزولههای باسیلوس تورنجینسیس انجام شد. تیمار رده سلولی سرطان سینه 4T1 با توکسین فعال شده انجام شد. از اثرات سیتوپاتیک سلولی عکسبرداری شد. توکسین کریستالی با بیشترین خاصیت سیتوسیدالی، با استفاده از SDS-PA...
Objective(s): Somatostatin receptor-positive neuroendocrine tumors have been targeted using various peptide analogs radiolabeled with therapeutic radionuclides for years. The better biomedical properties of radioantagonists as higher tumor uptake make these radioligands more attractive than agonists for somatostatin receptor-targeted radionuclide therapy. In this study...
رزین گام کندر که به خانواده بورسراسه تعلق دارد، بطور گسترده در درمان طیف وسیعی از بیماری ها استفاده می شود. با وجود اهمیت تاریخی و پزشکی آن، کندر به طور کامل مورد مطالعه قرار نگرفته و هنوز شکاف زیادی بین دانش سنتی استفاد از کندر و مستندات جدید علمی وجود دارد. این ماده طبیعی طی قرن ها برای جلوگیری از فراموشی و بهبود حافظه استفاده شده است، اما نحوه اثرگذاری آن بر روی حافظه و به عبارتی مکانسیم ملک...
DNA topoisomerase I (topo I) has been identified as a principal target of a plant alkaloid camptothecin (CPT) and its derivative (CPT-11). The latter compound is expected to be a clinically useful antitumor agent. Three human tumor cell lines resistant to CPT (A549/CPT, HT-29/CPT, St-4/CPT) were isolated in vitro, and a murine tumor cell line resistant to CPT-11 (P388/CPT) was isolated in vivo ...
Commensal Escherichia coli form biofilms at body temperature by expressing the extracellular matrix components curli fimbriae and cellulose. The role of curli fimbriae and cellulose in the interaction of commensal E. coli with the intestinal epithelial cell line HT-29 was investigated. Expression of curli fimbriae by the typical commensal isolate E. coli TOB1 caused adherence and internalizatio...
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