SARSA is a web tool that can be used to align two or more RNA tertiary structures. The basic idea behind SARSA is that we use the vector quantization approach to derive a structural alphabet (SA) of 23 nucleotide conformations, via which we transform RNA 3D structures into 1D sequences of SA letters and then utilize classical sequence alignment methods to compare these 1D SA-encoded sequences a...

BACKGROUND Japanese encephalitis (JE) causes inflammation of brain. The mortality rate due to JE is 30% while 10 -15 % of patients make full recovery. The disease spreads through infected mosquito bites breeding in rice fields and feeds on pigs, birds, and ducks. PURPOSE As proteins show important structure to function relationship the study was designed to carry out the identification of pol...

Small-animal positron-emission tomography/computed tomography (PET/CT) scanners provide anatomical and molecular imaging, which enables the joint visualization and analysis of both types of data. A proper alignment calibration procedure is essential for small-animal imaging since resolution is much higher than that in human devices. This work presents an alignment phantom and two different cali...

The measurement of independent sets of NMR residual dipolar couplings (RDCs) in multiple alignment media can provide a detailed view of biomolecular structure and dynamics, yet remains experimentally challenging. It is demonstrated here that independent sets of RDCs can be measured for ubiquitin using just a single alignment medium composed of aligned bacteriophage Pf1 particles embedded in a s...

Little is understood about the process of alignment of information systems (IS). While the MIT90s model presents one view of how various firm elements are involved in alignment, other research presents alternative paths. These paths are based on research in large businesses and none of the models have been applied to small firms (SMEs). Using multiple case data, this paper investigates alignmen...

A current, popular, theory of spatial localization holds that the visual system represents the location of simple objects by a single positional tag, the accuracy of which is largely independent of the internal properties of the object. We have already presented evidence of the limitations of such a view (Keeble & Hess (1998). Vision Research, 38, 827-840) in that 3-micropattern alignment perfo...

Our research addresses one of the most conspicuous and enduring issues facing IT practitioners: how to align a firm’s IT resources with its business needs. Past work in this area has been largely atheoretical and sometimes inconsistent. We seek to provide an internally consistent explanation of how organizations achieve alignment and thereby improve business performance. Our work differs from p...

We investigate the shapes and mutual alignment of voids in the large scale matter distribution of a ΛCDM cosmology simulation. The voids are identified using the novel WVF void finder technique. The identified voids are quite nonspherical and slightly prolate, with axis ratios in the order of c : b : a ≈ 0.5 : 0.7 : 1. Their orientations are strongly correlated with significant alignments spann...