A virtual duplex system can be used to increase safety without the use of structural redundancy on a single machine. If a program P is calculating a given function f, then a virtual duplex system contains two variants Pa and Pb of P which are calculating the diverse functions fa and fb , respectively. If no error occurs in the process of designing and executing Pa and Pb then f = fa = fb holds....

ix Chapter I: Introduction DNA DAMAGE RESPONSE 1 DNA DAMAGE REPAIR DNA modifications 3 Repair of double stranded DNA breaks 7 DNA DAMAGE RESPONSE PATHWAYS AND CANCER The link between the FA/BRCA pathway and cancer 8 The FA/BRCA pathway DNA damage response 11 FA/BRCA proteins and DNA damage repair 14 FA/BRCA proteins and cell cycle checkpoint 17 The link between the Mismatch repair pathway and c...

We report potent inhibition of the Mg(II).ATP-dependent protein phosphatase, Fc.M, by the regulatory subunit dimer of type II cAMP-dependent protein kinase, RII2. The protein kinase catalytic subunit has no effect on phosphatase activity and is unable to substitute for kinase FA in the kinase FA- and Mg(II).ATP-mediated phosphatase activation reaction. Phosphatase inhibition was investigated as...

Fanconi anemia (FA) is a cancer-predisposition syndrome characterized by hypersensitivity to interstrand-cross-link (ICL) inducers. FA hypersensitivity to ICL has been correlated with alterations in homologous recombination, non-homologous end-joining, telomere maintenance, DNA-damage assessment and checkpoint regulation, processes in which the components of the RAD50/MRE11/NBS1 (RMN) complex a...

The fatty acid (FA) docosahexaenoic acid (DHA, 22: 6n-3) is highly enriched in membrane phospholipids of the central nervous system and retina. Loss of DHA because of n-3 FA deficiency leads to suboptimal function in learning, memory, olfactory-based discrimination, spatial learning, and visual acuity. G protein-coupled receptor (GPCR) signal transduction is a common signaling motif in these ne...

The aim of the present study was to examine the apoptosis of the hepatocellular carcinoma cell line, HepG2, induced by treatment with folic acid-conjugated silica-coated gold nanorods (GNRs@SiO2-FA) in combination with radiotherapy, and to determine the involvement of apoptosis-related proteins. An MTT colorimetric assay was used to assess the biocompatibility of GNRs@SiO2-FA. The distribution ...

This study used thermal power plant fly ash (FA) and bottom (BA) as fill materials investigated the properties of composites made cement pine tree resin binders. For each group, 36 samples were prepared by adding 50% 1% to 2% i) FA had 23.18%, 22.99%, 77.01% lower density, conductivity, compressive strength than BA samples, respectively. 9.42% higher porosity samples. ii) (0.177 W/mK) (0.221 wi...

The use of microalgae as natural biofertilizer in horticulture has recently been reported, while the humic substances is widespread. However, combined with applied to plant leaves still unexploited. Thus, objective this work was combine fulvic acid (FA) Scenedesmus subspicatus microalga biomass (SC) a via leaf two onion cultivars organic system. Four experiments were conducted: i) bioassays ver...

BACKGROUND Unlike metastatic colorectal cancer (CRC) there are to date few reports concerning the predictive value of molecular biomarkers on the clinical outcome in stage II/III CRC patients receiving adjuvant chemotherapy. Aim of this study was to assess the predictive value of proteins related with the EGFR- and VEGFR- signalling cascades in these patients. METHODS The patients' data exami...