Lysostaphin is under development as a therapy for serious staphylococcal infections. During preclinical development, lysostaphin-resistant Staphylococcus aureus variants have occasionally been reported in vitro and in vivo. The acquisition of resistance to this drug, however, leads to a significant increase in beta-lactam antibiotic susceptibility, rendering methicillin-resistant S. aureus (MRS...

19. T. Oka, J. Mol. Spectrosc. 228, 635–639 (2004). 20. Here J denotes the rotational quantum number comprising end-over-end rotation R and internal rotation. 21. P. Bunker, B. Ostojić, S. Yurchenko, J. Mol. Struct. 695–696, 253 (2004). 22. Here we use the quantum number J instead of R, because the rotational motion in the state is not purely the end-over-end rotation. 23. M. Kolbuszewski, P. R...

‘The definitive property of individuality at the organismal level lies in the effective suppression of the differential propagation of subparts as a necessary strategy for maintaining functional integrity . . . This suppression has been so effective, while the consequences of failure remain so devastating, that human organisms have coined a word for the cell lineage’s major category of escape f...

Introduction: The US Federal Emergency Management Agency (FEMA) has created a publicly available National Risk Index (NRI) using natural disaster and community risk factor data to provide numeric visual representations of communities’ risk. Of particular interest is the index’s use social vulnerability resilience variables. This study’s purpose was identify explore differences in based on racia...

The potential for the development of resistance in oxacillin-resistant Staphylococcus aureus (ORSA) to lysostaphin, a glycylglycine endopeptidase produced by Staphylococcus simulans biovar staphylolyticus, was examined in vitro and in an in vivo model of infection. Following in vitro exposure of ORSA to subinhibitory concentrations of lysostaphin, lysostaphin-resistant mutants were idenitifed a...

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Evidence indicates that the dynamic behavior of Rigid Wall – Flexible Diaphragm (RWFD) structures is dominated by the diaphragm’s response instead of the walls’ response, and this is a significant departure from the underlying assumptions of the widely used equivalent lateral force method in current building codes. RWFD buildings are common in North America and other parts of the world, and inc...