نتایج جستجو برای: خونریزی ساب آراکنوئید sah

تعداد نتایج: 6650  

2011
Zhong Wang Gang Zuo Xiao-Yong Shi Jian Zhang Qi Fang Gang Chen

Our previous study concerning brain trauma has shown that progesterone could regulate toll-like receptor 4 (TLR4) and nuclear factor-kappa B (NF-κB) signaling pathway in the brain, which also has been proved to play important roles in early brain injury (EBI) after subarachnoid hemorrhage (SAH). The aim of the current study was to investigate whether progesterone administration modulated TLR4/N...

Journal: :Seizure 2012
Stacy W. Hill Shawn D. Gale Caleb Pearson Kris Smith

PURPOSE The present study provides a detailed account of neurocognitive outcome following minimal access subtemporal selective amygdalohippocampectomy (SAH) and establishes rates of neurocognitive decline in the largest sample to date. Use of a subtemporal surgical approach to SAH has been proposed to possibly reduce the risk for postoperative neurocognitive decline since lateral neocortical ti...

Journal: :Journal of nutritional science and vitaminology 2006
Yasuka Isa Tomoyuki Mishima Haruhito Tsuge Takashi Hayakawa

The objective of this study was to examine how transient high plasma homocysteine (Hcy) levels affect the metabolism of Hcy, the activity and expression of S-adenosylhomocysteine (SAH) hydrolase which catalyzes both SAH hydrolysis and SAH synthesis. Wistar ST rats (males) were cannulated in the right jugular vein for intravenous infusion of physiological saline or DL-Hcy solutions (15 and 30 mg...

2014
Chia-Mao Chang Yu-Feng Su Chih-Zen Chang Chia-Li Chung Yee-Jean Tsai Joon-Khim Loh Chih-Lung Lin

Cerebral vasospasm is the leading cause of mortality and morbidity in patients after aneurysmal subarachnoid hemorrhage (SAH). However, the mechanism and adequate treatment of vasospasm are still elusive. In the present study, we evaluate the effect and possible mechanism of progesterone on SAH-induced vasospasm in a two-hemorrhage rodent model of SAH. Progesterone (8 mg/kg) was subcutaneously ...

2014
Brandon A Miller Nefize Turan Monica Chau Gustavo Pradilla

Subarachnoid hemorrhage (SAH) can lead to devastating neurological outcomes, and there are few pharmacologic treatments available for treating this condition. Both animal and human studies provide evidence of inflammation being a driving force behind the pathology of SAH, leading to both direct brain injury and vasospasm, which in turn leads to ischemic brain injury. Several inflammatory mediat...

2016
Mingchang Li Wei Wang Haojian Mai Xinmu Zhang Jian Wang Yufeng Gao Yuefei Wang Gang Deng Ling Gao Shuanhu Zhou Qianxue Chen Xin Wang

Subarachnoid hemorrhage (SAH) results in significant nerve dysfunction, such as hemiplegia, mood disorders, cognitive and memory impairment. Currently, no clear measures can reduce brain nerve damage. The study of brain nerve protection after SAH is of great significance. We aim to evaluate the protective effects and the possible mechanism of methazolamide in C57BL/6J SAH animal model in vivo a...

2010
David M. Lemonick

Headache is a common chief complaint in primary and ambulatory care settings. The etiology of headache is usually benign, its workup is often minimal and straightforward, and the clinical approach focuses primarily on symptom control. A small proportion of headaches is caused by subarachnoid hemorrhage (SAH), most of which are due to ruptured cerebral aneurysms. Such hemorrhage carries a high m...

2016
Aida Maddahi

Background: Subarachnoid hemorrhage (SAH) is associated with high morbidity and mortality. It is suggested that the associated inflammation is mediated through activation of the mitogen-activated protein kinase (MAPK) pathway which plays a crucial role in the pathogenesis of delayed cerebral ischemia after SAH. The aim of this study was first to investigate the timecourse of altered expression ...

2014
Juergen Konczalla Johannes Platz Patrick Schuss Hartmut Vatter Volker Seifert Erdem Güresir

BACKGROUND Subarachnoid hemorrhage (SAH) is mainly caused by ruptured cerebral aneurysms but in up to 15% of patients with SAH no bleeding source could be identified. Our objective was to analyze patient characteristics, clinical outcome and prognostic factors in patients suffering from non-aneurysmal SAH. METHODS From 1999 to 2009, data of 125 patients with non-aneurysmal SAH were prospectiv...

Journal: :Stroke 2017
Lei Liu Fumihiro Kawakita Masashi Fujimoto Fumi Nakano Kyoko Imanaka-Yoshida Toshimichi Yoshida Hidenori Suzuki

BACKGROUND AND PURPOSE A matricellular protein tenascin-C is implicated in early brain injury after experimental subarachnoid hemorrhage (SAH). This study first evaluated the role of another matricellular protein periostin and the relationships with tenascin-C in post-SAH early brain injury. METHODS Wild-type (n=226) and tenascin-C knockout (n=9) C57BL/6 male adult mice underwent sham or fila...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید