Human UMP/CMP kinase (cytidylate kinase; EC 2.7.4.14) is responsible for phosphorylation of CMP, UMP, and deoxycytidine monophosphate (dCMP) and also plays an important role in the activation of pyrimidine analogs, some of which are clinically useful anticancer or antiviral drugs. Previous kinetic data using recombinant or highly purified human UMP/CMP kinase showed that dCMP, as well as pyrimi...

SpĂĄnkovĂŠ poruchy dĂ˝chania predstavujĂş vĂ˝znamnĂ˝ rizikovĂ˝ faktor cerebrovaskulĂĄrnych ochorenĂ­. SyndrĂłm spĂĄnkovĂŠho apnoe (SAS) je u pacientov s cievnou mozgovou prĂ­hodou (CMP) častĂ˝ a nepriaznivo ovplyvňuje ich zdravotnĂ˝ stav. Napriek tomu ostĂĄva veÄžkĂĄ časĹĽ CMP po tejto strĂĄnke nediagnostikovanĂ˝ch prichĂĄdza o potenciĂĄlny benefit pretlakovej ventilačnej liečby. V tomto Ä...

Chemical mechanical polishing (CMP) is an essential planarization process for semiconductor manufacturing. The application of CMP has been increasing in fabrication highly integrated devices. Recently, environmental burden caused by the was assessed because interest global environment. In this study, previously reported impacts on environment and studies conducted developing various methods to ...

Phosphorylation of deoxycytidine analogs by cellular enzymes is a prerequisite for the activity of these compounds. We have investigated the kinetic parameters for the phosphorylation of 1-beta-D-arabinofuranosylcytosine (araC) and 2', 2'-difluorodeoxycytidine (dFdC) to their diphosphate forms catalyzed by human UMP-CMP kinase. We cloned the cDNA of this enzyme to enable characterization of the...

Pyrimidine nucleoside monophosphate kinase [UMP/CMP kinase (UMP/CMPK);EC 2.7.4.14] plays a crucial role in the formation of UDP, CDP, and dCDP, which are required for cellular nucleic acid synthesis. Several cytidine and deoxycytidine analogues are important anticancer and antiviral drugs. These drugs require stepwise phosphorylation to their triphosphate forms to exert their therapeutic effect...

As a crucial substrate material for optoelectronic materials, sapphire has important applications in both military and civilian fields. In order to achieve the final processing quality of double-sided chemical mechanical polishing (DS-CMP) is necessary process, which also guarantee preparation high-end LED chips. this article, DS-CMP plan based on Box-Behnken design obtained experimented. Then,...

In order to promote Conceptual-Model Programming (CMP), we set forth these CMP Articles. We hold these articles to be the defining principles for model-complete software development. In essence, this CMP manifesto asserts that programming activities are to be carried out via conceptual modeling. For applications amenable to conceptual-model designs, software developers should never need to writ...

Chemical–mechanical polishing (CMP) is a process that planarizes semiconductor surfaces and essential for the manufacture of highly integrated devices. In CMP, pad conditioning using disk with diamond grit adopted to maintain surface roughness remove debris. However, uneven wear by unavoidable in CMP. this study, we propose contact-area-changeable system utilize it conduct preliminary study imp...

A CHO mutant line, MAR-11, was isolated using a cytotoxic lectin, Maackia amurensis agglutinin (MAA). This mutant has decreased levels of cell surface sialic acid relative to both wild-type CHO-K1 and Lec2 mutant CHO cells. The CMP-sialic acid transporter (CMP-SAT) gene in the MAR-11 mutant cell has a C-T mutation that results in a premature stop codon. As a result, MAR-11 cells express a trunc...