Several lines of evidence suggest that stem cells are major targets for carcinogens. A normal human breast epithelial cell type was previously shown to possess stem cell characteristics. Further cell lines were derived following sequential transfection with SV40 large T-antigen (immortal, non-tumorigenic M13SV1 cells), exposure to X-rays (weakly tumorigenic M13SV1R2 cells), and ectopic expressi...

Glomerular epithelial cells are primary pathogenic sites in focal segmental glomerulosclerosis (FGS) lesions. Glomerular epithelial cells are regarded as terminally differentiated cells that do not proliferate. These characteristics are also noted for neurons and muscular cells, which are major sites of mitochondrial DNA (mtDNA) mutation accumulation. Screening for mtDNA mutations was performed...

Extremely variable clinic and genetic features characterize mitochondrial encephalomyopathy (MEM). Pathogenic mitochondrial DNA (mtDNA) defects can be divided into large-scale rearrangements and single point mutations. Clinical manifestations become evident when a threshold percentage of the total mtDNA is mutated. In some MEM, the "mutant load" in an affected tissue is directly related to the ...

We describe the author’s research with Neil Strickland on the global algebra and global homological algebra of the category of BP∗BP comodules. We show, following [HS02a], that the category of E(n)∗E(n)comodules is a localization, in the abelian sense, of the category of BP∗BP comodules. This gives analogues of the usual structure theorems, such as the Landweber filtration theorem, for E(n)∗E(n...

Életútja a 20. század történelmi fordulatait követte. A „boldog békeidők” szülötte, tanulmányi évei még Horthy-korszak nyugodt idejére estek, de pályakezdését már második világégés árnyékolta be, mégis szerencsés és ígéretes indulásnak mondható. Királyi Magyar Pázmány Péter Tudományegyetem bölcsészeti karának történelem–földrajz szakos hallgatója 1931–1935 között. Az egyetem elvégzése után bécs...