Purpose: To determine the effect of melatonin in combination with capecitabine on proliferation and induction apoptosis MCF-7 SK-BR-3 breast cancer cell lines.Methods: The MTT assay (3- (4,5-dimethylthiazol-2-yl) -2,5-diphenyltetrazolium bromide) was performed to investigate lines half-maximal concentration (IC50) index. Expression apoptotic markers, Bax, Bcl-2, caspase-3 were measured by polym...

3,4- Methylenedioxymethamphetamine (MDMA or "Ecstasy") is a psychoactive and hallucinogenic drug of abuse. MDMA has been shown to produce neurotoxicity both in animals and humans. Recently, the vasodilator drugs such as pentoxifylline is one of the new strategies which have been considered as neuroprotector. In this study effect of pentoxifylline on bcl-2 gene expression changes in hippocampus ...

ischemia-reperfusion injury is the tissue damage caused when blood supply returns to the tissue after a period of ischemia or lack of oxygen. ischemia-reperfusion brain injury initiates an inflammatory response involving the expression of adhesion molecules and cytokines. twenty–four male wistar rats (250-300 g body wt) were used in this study. the animals were divided into four groups of 6 rat...

background: solid ameloblastoma (sab) is an invasive tumor which infiltrates adjacent normal tissues. adenomatoid odontogenic tumor is a noninvasive tumor and never infiltrates surrounding normal tissues. the purpose of this study was to determine the biological behavior of these two epithelial odontogenic neoplasm by detecting ki-67 and bcl-2, which are mitotic and anti apoptotic markers respe...