Abstract Novel hydrazone and 1,2,4-triazole-3-thione derivatives were obtained via the reaction of N 1 , 3 ,2-triaryl-6-hydroxy-6-methyl-4-oxocyclohexane-1,3-dicarboxamides with acid hydrazides thiosemicarbazide, respectively. Structure products was proved using IR H NMR spectroscopy methods. Some synthesized compounds tested for antimicrobial activity

Eight new Schiff bases of 5-nitro and 5-bromo-substituted 1,10-phenanthroline-2,9-dicarboxaldehydes with sulfur-containing amines, thiosemicarbazide, S-alkyl/aryl dithiocarbazates and 2-mercaptoaniline have been synthesized and characterized by a variety of spectroscopic methods. The condensation reactions of the dialdehydes with the amines were carried out both in the presence and absence of c...

The asymmetric unit of the title compound, C(8)H(9)N(3)O(2)S·0.5H(2)O, contains two thiosemicarbazide mol-ecules with the short distance of 3.521 (3) Å between the centroids of the benzene rings, and one water mol-ecule. In the two independent mol-ecules, the benzene rings and the thio-semicarbazone fragments are twisted at 9.2 (3) and 18.5 (3)°. An extensive three-dimensional hydrogen-bonding ...

Thiazoles and thiazolyl-pyrazole derivatives have been efficiently synthesized under neat reaction conditions in excellent yields. Condensation of 3-(2-bromoacetyl)-4-hydroxy-6-methyl-2H-pyran-2-one (1), thiosemicarbazide (2) and various carbonyl compounds (3 & 5) gave corresponding thiazole (4) and thiazolylpyrazole derivatives (6) in excellent yields by using Hantzsch-Thiazole synthesis. The ...

A series of 4-arylthiosemicarbazides substituted at the N1 position with a 5-membered heteroaryl ring was synthesized and evaluated in vitro for T. gondii inhibition proliferation and host cell cytotoxicity. At non-toxic concentrations for the host cells all studied compounds displayed excellent anti-parasitic effects when compared to sulfadiazine, indicating a high selectivity of their anti-T....