The cellular delivery of short interfering RNA (siRNA) is a main hurdle in therapeutic drug development. Here, we describe that phosphorothioate (PTO)-derived oligonucleotides stimulate the physical cellular uptake of siRNA in trans in human cells. This is reflected by an apparent dose-dependent siRNA-mediated suppression of lamin A/C in primary human umbilical vein endothelial cells. The PTO-s...

The possibility of weighting QALYs differently for different groups of patients has been a source of debate. Most recently, this debate has been extended to the relative value of QALYs at the end of life (EoL). The objective of this study is to provide evidence of societal preferences in relation to this topic. Three cross-sectional surveys were conducted amongst Spanish general population (n =...

Received: May 08, 2017; Accepted: May 19, 2017; Published: May 22, 2017 A 49-year-old man was referred to us with a diagnosis of hematemesis by giant pipeline esophageal varices due to liver cirrhosis hepatitis C infection after carving a tattoo at 20-year age (Figures 1A & 1B). We reviewed the treatment strategy. Endoscopic injection sclerotherapy (EIS) was generally treated esophageal varices...

In this paper, a concept of floating elastic wave energy converter consisting disk-shaped plate is proposed. The moored to the seabed through series power take-off (PTO) units. A theoretical model based on linear potential flow theory and eigenfunction matching method developed study hydroelastic characteristics evaluate absorption device. PTO system simulated as discrete PTO, moreover, it also...

A hybrid system integrating a power take-off (PTO) into floating breakwater is promising candidate for both shoreline protection and commercial wave energy extraction. Although geometric asymmetry important to such PTO-integrated breakwaters, its role in conversion efficiency attenuation poorly understood. In this study, two-dimensional semi-analytical model dealing with floats arbitrary bottom...

This paper uses a fully nonlinear model to comprehensively explore the coupled effects caused by system integration between an offshore wind turbine and heaving buoy wave energy converter. Parameters of study include pitch motion turbine, tension on mooring line, contact pressure these two devices, absorbed power take-off (PTO) system. Results demonstrated that stabilises/reduces when its metac...

Although the molecular basis of poplar sex-specific flower development remains largely unknown, increasing evidence indicates an essential role for microRNAs (miRNAs). The specific miRNA types and precise miRNA expression patterns in dioecious plant flower development remain unclear. Here, we used andromonoecious poplar, an exceptional model system, to eliminate the confounding effects of genet...

PURPOSE The purpose of this study was to document results of a less invasive technique of open wedge proximal tibial osteotomy (PTO) for the varus knee in young adults using an intramedullary tibial nail. MATERIALS AND METHODS We prospectively studied 24 knees in 16 young patients with varus knee deformity. The mean follow-up was 54 months (range, 36 to 107 months) and the mean age of patient...

RPM1-interacting protein 4 (RIN4), a negative regulator of the basal defense response in plants, is targeted by multiple bacterial virulence effectors. We show that RIN4 degradation is induced by the effector AvrPto from Pseudomonas syringae and that this degradation in Solanaceous plants is dependent on the resistance protein, Pto, a protein kinase, and Prf, a nucleotide binding site–leucine-r...