Morphine is recommended as a first-line opioid analgesic in the pain management of cancer patients. Accumulating evidence shows that morphine has anti-apoptotic activity, but its impact on the therapeutic applications of antineoplastic drugs is not well known. The present study was undertaken to test the hypothesis that morphine might antagonize the pro-apoptotic activity of DOX (doxorubicin), ...

introduction: ghrelin is an endogenous peptide that has diverse functions in the body. one of the newly recognized roles of this peptide is its antiapoptotic effect. however, this function has not been investigated in normobaric hypoxia- induced apoptosis in body organs. this study will examine the effect of ghrelin treatment on bax-bcl-2 gene expression in the kidney of chronic hypoxic rats. m...

Accumulation of α‑synuclein (α‑SYN) is a common pathology for Parkinson's disease (PD). There is abundant evidence that the toxic‑gain‑of‑function of α‑SYN's is associated with aggregation and consequent effects. To assess the potential of chondroitin sulfate (CS) in this regard, the present study investigated its neuroprotective on SH‑SY5Y cells overexpressing wild‑type (WT) or A53T mutant α‑S...

OBJECTIVES We aimed to investigate the protective effect of Lycium barbarum polysaccharides (LBPs) against oxidative stress-induced apoptosis and senescence in human lens epithelial cells. METHODS To study apoptosis, SRA01/04 cells, a human lens epithelial cell lines, were exposed to 200 µM hydrogen peroxide (H2O2) for 24 h with or without pretreatment with LBPs. Cell viability was measured u...

Diosgenin, a naturally occurring steroid saponin found abundantly in legumes and yams, is a precursor of various synthetic steroidal drugs. Diosgenin is studied for the mechanism of its action in apoptotic pathway in human hepatocellular carcinoma cells. Based on DAPI staining, diosgenin-treated cells manifested nuclear shrinkage, condensation, and fragmentation. Treatment of HepG2 cells with 4...

Although Bcl-2 family proteins were originally identified as key regulators of apoptosis, an impressive body of evidence has shown that pro-survival members of the Bcl-2 family, including Bcl-2, Bcl-XL, and Bcl-w, can also promote cell migration, invasion, and cancer metastasis. Interestingly, cell invasion was recently found to be suppressed by multidomain pro-apoptotic members of the Bcl-2 fa...

background and objectives: giant cell tumor of bone (gct) is often regarded as a benign tumor, but its clinical course is unpredictable, has a high rate of recurrence, and even can metastases and transform to a malignant tumor. histological features of the tumor often could not predict its future biologic behavior, so it is just called ''giant cell tumor'' without indicating malignancy or benig...

Lung cancer is the second leading cause of cancer-related mortalities globally. Failure in diagnosis at early stages and limited effective chemotherapeutics has severely impeded clinical management patients suffering from lung carcinoma. At present, researchers across world are focused on exploring biologically active natural products for treating various cancers, which can thus be further inve...

Cancer is one of the diseases that threatens human health and a leading cause mortality worldwide. High levels reactive oxygen species (ROS) have been observed in cancer tissues compared with normal vivo, it not yet known how this influences chemotherapeutic drug action. Cationic porphyrin 5,10,15,20-tetra-(N-methyl-4-pyridyl) (TMPyP4) photosensitizer used photodynamic therapy (PDT) telomerase ...