In MINDACT trial, 4 risk categories (RC) by clinical (c) and genomic (g) breast cancer (BC) were defined. The study showed that the cHigh/gLow group without chemotherapy (CT) had a 94.8 % (CI 95% 92.9-96-2) 5-year Distant Metastases Free Survival (DMFS), so meeting trial primary objective. Recently, MP g with excellent prognosis, named ultralow (gUL), has been described (15% in MINDACT). Howeve...

Neurokinins (substance P, neurokinin A and neurokinin B) and the neurokinin receptors, the NK1 and NK3 receptors, are largely expressed in the nucleus of the solitary tract (NST) where they are involved in the central regulation of visceral function. Studying the mechanisms that control neurokinin release can provide valuable information concerning the control of autonomic functions subserved b...

The present study used activation of the c-Fos oncogene protein within neurons in the dorsal vagal complex (DVC) as a marker of neuronal excitation in response to systemic endotoxin challenge [i.e. , lipopolysaccharide (LPS)]. Specifically, we investigated whether vagal connections with the brain stem are necessary for LPS cytokine- induced activation of DVC neurons. Systemic exposure to LPS el...

Wheat germ agglutinin (WGA) has been known to be transported easily to terminals from neuronal cell bodies and pass through synapses. In the present fluorescent experiments, coinjection of fluorescent WGA (FWGA) with F-Amyloid-β (FAβ) into one side of the vagus nerve (VN) at the cervical portion of the rats resulted in heavy labeling of these substances in the nodose ganglion (NG) and nucleus o...

Previous light microscopic work in the rat has demonstrated that many dendrites of vagal gastric motoneurons extend beyond the cytoarchitectural boundaries of the dorsal motor nucleus of the vagus (DMV) into the nucleus of the solitary tract (NST), where they overlap with the central terminal field of vagal gastric primary sensory neurons (Shapiro and Miselis, 1985a). In the present ultrastruct...

AIM OF THE STUDY Atherosclerosis represents active inflammation in which leukocytes play significant role. Coronary collateral development is a response to myocardial ischaemia. In this study we aimed to investigate the association of the leukocytes with coronary collateral development in patients with non ST-elevated acute coronary syndromes (NST-ACS). MATERIAL AND METHODS A total of 251 con...

Despite their lack of brown adipose tissue, some bird species develop regulatory non-shivering thermogenesis (NST) of skeletal muscle origin in response to cold acclimation. Mechanisms involved in avian NST are still unclear but may involve reduced energetic coupling in skeletal muscle mitochondria through the expression of an avian homologue of mammalian uncoupling proteins. The aim of this wo...

Introduction Invasive ductal carcinoma (IDC) is the most common type of breast cancer in women and accounts for about 80% of all breast cancers. Material and methods The material consisted of histological preparations derived from 691 patients treated for IDC-NST. Results In our own study material, invasive ductal breast cancer of no special type accounted for more than 60% of cases, with t...