OBJECTIVE To explore the effects of renal sympathetic denervation (RSD) on pulmonary vascular remodeling in a model of pulmonary arterial hypertension (PAH). METHODS According to the random number table, 24 beagles were randomized into control, PAH and PAH+RSD groups (n=8 each). The levels of neurohormone, echocardiogram and dynamics parameters were measured. Then 0.1 ml/kg dimethylformamide ...

Background—Incidence and prevalence rates for pediatric pulmonary hypertension (PH) and pulmonary arterial hypertension (PAH) are unknown. This study describes the nationwide epidemiological features of pediatric PH in the Netherlands during a 15-year period and the clinical course of pediatric PAH. Methods and Results—Two registries were used to retrospectively identify children (0–17 years) w...

This statement of clinical guidelines, although at times subjective in its ratings of evidence, is valuable as an overview of the field of pulmonary hypertension and comprehensive in its review of the extant literature. Sections include diagnosis and management of pulmonary arterial hypertension (PAH); methodology and grading for pulmonary hypertension evidence review and guideline development;...

The objectives of this work assignment were to evaluate ELISA screening methods and determine whether these methods indicate effectively those microenvironments where high exposure to polycyclic aromatic hydrocarbons (PAH) or other semivolatile organic compounds (SVOC) is likely. Four commercially available assay kits for PAH, carcinogenic PAH (C-PAH), 2,4-D, and pentachlorophenol (PCP) were ev...

Pulmonary arterial hypertension (PAH) is characterized by obstruction of pre-capillary pulmonary arteries, which leads to sustained elevation of pulmonary arterial pressure. Identifying those at risk through early interventions, such as genetic testing, may mitigate disease course. Current practice guidelines recommend genetic counseling and offering genetic testing to individuals with heritabl...

Recognition of pulmonary arterial hypertension (PAH) associated with systemic sclerosis (SSc) (SSc-PAH) is very important , because SSc-PAH is highly prevalent and is a leading cause of mortality in patients with SSc. 1)2) Despite the use of novel therapeutic strategies, response to PAH-targeted therapy is still insufficient in SSc-PAH, which is associated with poor prognosis in SSc-PAH. 3) Ind...

Polycyclic aromatic hydrocarbons (PAH) were determined in two sediment cores in urban Lake Bled (NW Slovenia). In surface sediments of the deep western basin, the total PAH concentration was 1150 ng g dry weight (dw), whereas in shallower, nearshore Zaka Bay the PAH concentration was 1900 ng g dw. Fourto six-ring PAH were the most abundant compounds, suggesting that most PAH in Lake Bled sedime...

N-terminal pro-brain natriuretic peptide (NT-proBNP) is a marker of neurohormonal activation that is useful in the diagnosis and prognosis of various forms of pulmonary arterial hypertension (PAH). We sought to characterise and compare NT-proBNP in a cohort of PAH related to systemic sclerosis (PAH-SSc) and idiopathic PAH (IPAH) patients. NT-proBNP levels, collected from PAH-SSc and IPAH patien...

Background: We aimed to evaluate the expression of cysteine rich 61 (Cyr61) in patients with pulmonary arterial hypertension (PAH) as well as monocrotaline (MCT) induced PAH rat, and further investigate the effects and potential mechanisms of Cyr61 on the proliferation of pulmonary arterial smooth muscle cells (PASMCs). Methods and Results: Plasma samples were collected from 20 patients with id...

Pulmonary arterial hypertension (PAH) is a serious complication of systemic sclerosis (SSc). In clinical trials PAH-SSc has been grouped with other forms, including idiopathic PAH. The primary endpoint for most pivotal studies was improvement in exercise capacity. However, composite clinical endpoints that better reflect long-term outcome may be more meaningful. We discuss potential endpoints a...