(3%) and MPL (3%). Interestingly, it has been hypothesized that MDS with ring sideroblasts (MDS-RS) can transform into MDS/MPN-RS-T with acquisition of the JAK-2 mutation. Poor prognostic factors in MDS/MPN-RS-T include older age (>80), low Hb (<8 g/dl), abnormal cytogenetics, the presence of SETBP-1 or ASXL-1 mutations and the absence of SF3B1 or JAK-2 mutations. It is interesting to compare o...

A method in the current literature used to estimate the density of bacteria in a sample solution is the most probable number (MPN) procedure. This paper considers the change in density of bacteria in the sample through time. The MPN with its variance for a fixed time point is just one module of the experiment and is treated as a generalization of the unrestricted maximum likelihood estimates us...

JAK2 V617F is the predominant driver mutation in patients with Philadelphia-negative myeloproliferative neoplasms (MPN). mutations are also frequent clonal hematopoiesis of indeterminate potential (CHIP) otherwise “healthy” individuals. However, period between acquisition and MPN diagnosis (known as latency) varies widely individuals, detectable several decades before even from birth some Here,...

In Indonesia, herbal medicine is still very popular, especially ginger and curcurma herbs. Both herbs are believed to increase the body's immunity for those who consume them. Processing of which carried out with simple process tools possible contamination by microbes. Coliform bacteria Escherichia coli used as indicators because habitat these two digestive tract or in rest feces. These can caus...

Polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF) are chronic myeloproliferative neoplasms (MPN) characterized by clonal expansion of an abnormal hematopoietic stem/progenitor cell. Their natural history is marked by thrombohemorrhagic complications and a propensity to transform into myelofibrosis and acute leukemia. The understanding of the MPN pathophysio...

Abstract Background and Aims Myeloproliferative neoplasms (MPN) are chronic blood disorders defined by an overproduction of clonal, differentiated hematopoietic cells. A high prevalence kidney disease (CKD) is described in patients with MPN. The glomerular histological pattern MPN-related disease, glomerulopathy (MPN-RG), may not account for the entirety CKD risk this population, as it appears ...

Interest in systematic reviews and meta-analysis in medicine began in the late 1970s. During the 1980s, these methods began to be adopted more widely by medical researchers, and in the late 1980s, expository journal articles began to appear, and the first book about meta-analysis in medicine was published. The book was published in 1987 by Milos Jenicek, a professor at the Université de Montréa...