Chronic metabolic acidosis increased the Na+-H+ exchange activity in isolated renal brush-border membrane vesicles. Treatment altered the initial rate of Na+ uptake by increasing Vm (acidotic, 15.3 +/- 0.7 nmol of Na+ X mg-1 X 2 s-1; normal, 11.3 +/- 0.9 nmol of Na+ X mg-1 X 2 s-1), and not the apparent affinity KNa+ (acidotic, 10.2 +/- 0.5 mM; normal 10.2 +/- 0.6 mM). Metabolic acidosis result...

BETZ, A. LORRIS, DAVID D. GILBOE, DAVID L. YUDILEVICH, AND LESTER R. DREWES. Kinefics of unidz’rechzal glucose fransport into the isoluted dog brain. Am. J. Physiol. 225(3): 586592* 1973.An indicator-dilution technique with 22Na as the intravascular marker was used to measure unidirectional transport of D-glucose6-3H from blood into the isolated dog brain. The rate of unidirectional glucose tra...

Familial adenomatous polyposis (FAP) is an inherited disorder caused by germline mutation of the adenomatous polyposis coli (APC) gene. Increased risk of hepatoblastoma (HBL) in FAP kindreds has been re ported. To determine whether inactivation of the APC gene plays a role in development of HBL, 13 sporadic infantile hepatic tumors were analyzed for genetic alterations in the APC gene. A PCR-me...

1. Abstract 2. Introduction 3. Materials and methods 3.1. Materials and media 3.1.1. Preparation of thymocytes 3.2. Mg loading procedure 3.3. Measurement of intracellular Na and Mg 3.4. Measurement of Nao-induced Mg efflux 3.5. Measurement of Nao-induced Mgit and Nait changes 3.6. Statistical analysis 4. Results 4.1. Nait and Mgit content 4.2. Plasmalemmal Mg leak was not enhanced by A-23187 Mg...

The administration of cortisone to rats and rabbits has been found to cause profound changes in the hepatic parenchyma; i.e . . . . increase in cell size, accumulation of glycogen, and greatly decreased cytophsmic basophilia which has been found not to be decreased further by treatment with ribonudease (1-4). Microscopic examination has also indicated a decrease in numbers of mitochondria and a...

The reaction between [XW(9)O(34)](9-) (X = As, P) and [RuC(6)H(6)Cl(2)](2) in aqueous buffer solution (pH 6.0) leads to the isolation of two pseudo-sandwich-type heteropolytungstates KNa(6)[(RuC(6)H(6))AsW(9)O(34)] x 17 H(2)O (As-1) and Na(7)[(RuC(6)H(6))PW(9)O(34)] x 14 H(2)O (P-2). Single-crystal X-ray diffraction analyses reveal that the two compounds have the following features: (1) in two ...