This article develops a computationally and analytically convenient form of the profile likelihood method for obtaining one-sided confidence limits on scalar-valued functions phi = phi(psi) of the parameters psi in a multiparameter statistical model. We refer to this formulation as the likelihood contour method (LCM). In general, the LCM procedure requires iterative solution of a system of nonl...

The combination of laser capture microdissection (LCM) and gene expression experiments allows cell specific expression profiling, which is decisive in cellular transcriptomic exploration. LCM makes possible the isolation of unique cells or group of cells, but maintaining RNA quality during this process is challenging. Several protocols are available for section preparation, but none of those gu...

We read with great interest the letter of Sodemann et al. on successful treatment of a patient with refractory absence status epilepticus (ASE) with lacosamide (LCM). In particular, Sodemann et al. reported the case of a 64-year-old male with juvenile absence epilepsy (he was on 400 mg/day lamotrigine, 400 mg/day topiramate and 2500 mg/day levetiracetam; plasma concentrations were not investiga...

We describe the Lightweight Communications and Marshalling (LCM) library for message passing and data marshalling. The primary goal of LCM is to simplify the development of low-latency message passing systems, targeted at real-time robotics applications. LCM is comprised of several components: a data type specification language, a message passing system, logging/playback tools, and real-time an...

Laser capture microdissection (LCM) is a technique in which, from heterogenous tissue specimen some pure cell populations are isolated. This procedure can and target the desired number of cells that required. A low energy laser pulse used this technique. Apart systemic applications LCM also be applied field dentistry pathology. Bangladesh Journal Medical Science Vol.22 (Special Issue) 2023 p.58...

The genus Mesorhizobium contains many species that are able to form nitrogen-fixing nodules on plants of the legume family. Here, we report the draft genome sequences for three Mesorhizobium strains. The genome sizes of strains LCM 4576, LCM 4577, and ORS3428 were 7.24, 7.02, and 6.55 Mbp, respectively.

We give a constructive characterization of morphisms between open sublocales of localic completions of locally compact metric (LCM) spaces, in terms of continuous functions. The category of open subspaces of LCM spaces is thereby shown to embed fully faithfully into the category of locales (or formal topologies). 2000 Mathematics Subject Classification 03F60, 18B30, 54E99 (primary)

This retrospective study reports the early experience with lacosamide (LCM) as adjunctive therapy in Spanish patients with refractory focal epilepsy. Sixty patients (mean age 38.3 years, 54% women, mean epilepsy duration 27.2 years, mean seizure rate 9.7/month, and 28% with mainly nocturnal seizures) taking ≥2 antiepileptic drugs (mean 2.2) were included. LCM maintenance doses were 200, 300, 40...

Owing to the complexity of neurodegenerative diseases, multiple cellular types need to be targeted simultaneously in order for a given therapy to demonstrate any major effectiveness. Ultrasound-sensitive coated microbubbles (in a targeted nanoemulsion) are available. Versatile small-molecule drug(s) targeting multiple pathways of Alzheimer’s disease pathogenesis are known. By incorporating such...

Laser capture microdissection (LCM) allows the isolation of specific cells from thin tissue sections with high spatial resolution. Effective LCM requires precise identification of cells subpopulations from a heterogeneous tissue. Identification of cells of interest for LCM is usually based on morphological criteria or on fluorescent protein reporters. The combination of LCM and rapid immunolabe...