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تعداد نتایج: 62513 فیلتر نتایج به سال:
Osteoporosis is a highly heritable trait that appears to be influenced by multiple genes. Genome-wide linkage studies have highlighted the chromosomal region 3p14-p21 as a quantitative trait locus for BMD. We have previously published evidence suggesting that the ARHGEF3 gene from this region is associated with BMD in women. The product of this gene activates the RHOA GTPase, the gene for which...
LYP, the protein product of the protein tyrosine phosphatase gene PTPN22 located on human chromosome 1p13.2, is involved in downregulation of T cell signaling through its interaction with C-terminal Src tyrosine kinase (Csk) (Cloutier and Veillette, 1996), by phosphorylation of regulatory tyrosines on the Src family kinase Lck (Cloutier and Veillette, 1999). A missense mutation of this gene (C1...
background: genetic diversity of three polymorphic markers in the phenylalanine hydroxylase (pah) gene region including pvu ii (a), pahstr and msp i were investigated. methods: unrelated individuals (n=139) from the iranian populations were genotyped using primers specific to pah gene markers including pvu ii(a), msp i and pahstr. the amplified products for pvu ii(a), msp i were digested using ...
Protein Tyrosine Phosphatase Gene PTPN22 Polymorphism in Psoriasis: Lack of Evidence for Association
LYP, the protein product of the protein tyrosine phosphatase gene PTPN22 located on human chromosome 1p13.2, is involved in downregulation of T cell signaling through its interaction with C-terminal Src tyrosine kinase (Csk) (Cloutier and Veillette, 1996), by phosphorylation of regulatory tyrosines on the Src family kinase Lck (Cloutier and Veillette, 1999). A missense mutation of this gene (C1...
هدف: کبد از حساس‌ترین بافت‌های هدف فشار اکسایشی ناشی تمرین می‌باشد و آمینوترانسفراز‌های کبدی، شاخص‌های حساسی برای تعیین آسیب دیدگی سلول‌های کبدی هستند. پژوهش حاضر با مقایسه تأثیر هشت هفته TRX مقاومتی سنتی بر برخی آنزیم‌های (آسپارتات آمینو ترانسفراز آلانین ترانسفراز) در زنان غیرفعال انجام گرفت.روش ها: این که به روش نیمه تجربی شد، 28 دختر میانگین سن41/1±07/21 سال شاخص توده بدن 25/4±52/22 کیلوگرم...
زمینه و هدف: بسیاری از عوامل محیطی جمله مداخلات غذایی می‌توانند التهاب را تعدیل کنند. پژوهش‌های قبلی تأیید کرده‌اند که وعده‌های چرب موجب افزایش فعال شدن نشانگرهای التهابی مانند IL-6 در مرحلة پس مصرف می‌شود. ازاین‌رو هدف این پژوهش بررسی اثر تمرین هوازی همراه با عصارة پوست سبز پسته بر بیان IL-6، IL-1 TNF-α بافت قلب موش‌های صحرایی تغذیه‌شده غذای بود.مواد روش‌ها: تحقیق مادة دوازده‌هفته‌ای وزن بین 1...
Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders with a strong genetic component. Many lines of evidence indicated that ASD shares common genetic variants with other psychiatric disorders (for example, schizophrenia). Previous studies detected that calcium channels are involved in the etiology of many psychiatric disorders including schizophrenia and autism. Significant...
PURPOSE To investigate the association of high myopia with polymorphisms in the hepatocyte growth factor (HGF) gene, a potential candidate for myopia development. METHODS Single nucleotide polymorphisms (SNPs) were screened and identified in the HGF gene region with denaturing high-performance liquid chromatography, and their linkage disequilibrium pattern was established in a Han Chinese pop...
Attention-deficit/hyperactivity disorder (ADHD) is typically characterized by inattention, excessive motor activity, impulsivity, and distractibility. Individuals with ADHD have significant impairment in family and peer relations, academic functioning, and show high co-morbidity with a wide range of psychiatric disorders including oppositional defiant disorder (ODD), conduct disorder (CD), anxi...
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