In the title compound, [Co(C(4)H(4)O(4))(C(9)H(7)N)(2)(H(2)O)(2)](n), the Co(II) cation, located on an inversion center, is coordinated by two succinate anions, two isoquinoline ligands and two water mol-ecules in a distorted octa-hedral geometry. The succinate anion, located across another inversion center, bridges the Co cations, forming polymeric chains running along the b axis. The partiall...

The in vitro antifungal potency of six series of 4-arylthiosemicarbazides was evaluated. Two isoquinoline derivatives with an ortho-methoxy or ortho-methyl group at the phenyl ring were the most potent antifungal agents. Molecular modeling studies and docking of all 4-arylthiosemicarbazides into the active sites of sterol 14α-demethylase (CYP51), topoisomerase II (topo II), L: -glutamine: D: -f...

The potential induction of a programmed cell death (PCD) in Trypanosoma b. brucei by 55 alkaloids of the quinoline, quinolizidine, isoquinoline, indole, terpene, tropane, steroid, and piperidine type was studied by measuring DNA fragmentation and changes in mitochondrial membrane potential. For comparison, the induction of apoptosis by the same alkaloids in human leukemia cells (Jurkat APO-S) w...

UNLABELLED Tetrahydropapaveroline and reticuline, isoquinoline alkaloids, were purified and identified in the pedal ganglia of the marine mollusk Mytilus edulis. OBJECTIVES To determine the presence of tetrahydropapaveroline and reticuline, isoquinoline alkaloids, in animal tissues previously shown to express opiate receptors. METHODS AND RESULTS This was achieved by high performance liquid...

A comparison between the reactivity behavior of two lutetium benzyl complexes supported by different ferrocene-diamide ligands towards aromatic N-heterocycles, such as 1-methylimidazole, isoquinoline, and pyridines, is presented. The two ferrocene-diamide ancillary ligands differ in their nitrogen-donor substituent: adamantyl for one and t-butyldimethylsilyl for the other. The synthesis and cha...

Radix isatidis (Banlangen), a famous traditional Chinese medicine, has been used for thousands of years in China due to its anti-viral activity. Through our research, we inferred that the anti-viral activity of Radix isatidis depended on the water-soluble part. Among the components of this extract, the isoquinoline derivative 1 was isolated for the first time and has shown better anti-viral act...

3-phenylaminoisoxazol-5(2h)-ones,s ubstituted on nitrogen with an isoquinoline or quinazoline group, react with tertiary amine bases to give imidazo annelated compounds. when the n-substituent is a nitropyridine, 2-aminoindole derivatives are formed instead. evidence is presented that the reactions proceed by initial addition of the tertiary arnine to c-4

A concise synthesis of the biologically active alkaloid berberine is reported, and a versatile palladium-catalyzed enolate arylation is used to form the isoquinoline core. The overall yield of 50 % is a large improvement over the single, previous synthesis. By design, this modular route allows the rapid synthesis of other members of the protoberberine family (e.g., pseudocoptisine and palmatine...

The induction of apoptosis by 66 alkaloids of the quinoline, quinolizidine, pyrrolizidine, isoquinoline, indole, terpene, tropane, steroid, purine, and piperidine type, of 9 cardiac glycosides, 11 non-protein amino acids and 10 further secondary metabolites was assayed in HL-60 cell cultures and measured by quantification of the subdiploid DNA content by flow cytometry, detection of DNA fragmen...