A 65-year-old female with biopsy-confirmed nephrogenic systemic fibrosis (NSF) received a kidney transplantation. Despite good kidney function, her symptoms continued to progress. Deferoxamine was administered intramuscularly at 500 mg/day and later 1000 mg/day after 1 week with no adverse effects. Urine excretion of gadolinium increased from 6.0 μg/day to 11.6 μg/day and subsequently to 13.0 μ...

In the next major topic of the course, we will be looking at probability. Suppose you toss a fair coin a thousand times. How likely is it that you get exactly 500 heads? And what about 1000 heads? It turns out that the chances of 500 heads are roughly 5%, whereas the chances of 1000 heads are so infinitesimally small that we may as well say that it is impossible. But before you can learn to com...

In studies on the distribution of lead in rats given drinking water containing lead acetate at concentrations: 0, 100, 500, 1000 and 5000 ,ugPb/l for one year, no change was observed in the organ distribution of lead, or in the subcellular distribution of lead in the organelles in the heart. The mitochondrial enzyme, ferrochelatase, was significantly depressed in both the 500 and 1000 ptg/l gro...

Background: Gastroschisis is a congenital malformation characterized by the extrusion of the fetal bowel during intrauterine life, secondary to a defect in anterior abdominal wall. Objective: To establish an experimental model of gastroschisis in fetuses of rats exposed to acetylsalicylic acid (ASA), during pregnancy. Methods: Wistar rats were treated with an oral single ASA dose of 50, 500, 75...

OBJECTIVES Ofatumumab is a human IgG1κ monoclonal antibody that targets a membrane proximal epitope encompassing the small and large loops of CD20. This Phase I study evaluated the safety, tolerability, efficacy and pharmacokinetics of ofatumumab monotherapy in Japanese patients with relapsed/refractory B-cell chronic lymphocytic leukemia and small lymphocytic lymphoma. METHODS Ofatumumab was...

Evaluation of aerobic fitness indicators in canoers reveals functional characteristics acquired through specific training, which can be related to competitive performance. Thus, the aim of the present study was to evaluate functional evaluators obtained in ergospirometry test of young canoers, as well as to verify the relationship of these variables with performance in 200, 500 and 1000 m dista...

Pharmacological and preventive properties of Petroselinum sativum seed extracts are well known, but the anticancer activity of alcoholic extracts and oil of Petroselinum sativum seeds on human breast cancer cells have not been explored so far. Therefore, the present study was designed to investigate the cytotoxic activities of these extracts against MCF-7 cells. Cells were exposed to 10 to 1000...

OBJECTIVES Rituximab is an effective treatment in patients with established rheumatoid arthritis (RA). The objective of the IMAGE study was to determine the efficacy of rituximab in the prevention of joint damage and its safety in combination with methotrexate (MTX) in patients initiating treatment with MTX. METHODS In this double-blind randomised controlled phase III study, 755 MTX-naïve pat...