A System of Systems (SoS) is an arrangement of useful and independent complex systems, which are integrated into a bigger system that delivers unique capabilities [1]. In this context, it is important to notice that each independent system should be capable of operate and fulfil useful purposes on its own environment, but, when these independent systems are together and become a SoS they are ab...

Effect-directed analysis (EDA) was performed to identify the major aryl hydrocarbon receptor (AhR) agonists in sediments collected from a highly industrialized area (Lake Shihwa, Korea). Great AhR-mediated potencies were found in fractions containing aromatic compounds with log Kow values of 5-8, and relatively great concentrations of styrene oligomers (SOs) and polycyclic aromatic hydrocarbons...

Systems of Systems (SoS) are a current focus of many organizations interested in integrating assets and utilizing new technology to create multi-component systems that deliver value over time. The dynamic composition of SoS along with the managerial independence of their component systems necessitates systems engineering considerations and methods beyond those of traditional systems engineering...

The DNA damage induced SOS response in Escherichia coli is initiated by cleavage of the LexA repressor through activation of RecA. Here we demonstrate that overexpression of the SOS-inducible tisAB gene inhibits several SOS functions in vivo. Wild-type E. coli overexpressing tisAB showed the same UV sensitivity as a lexA mutant carrying a noncleavable version of the LexA protein unable to induc...

BACKGROUND The anti-ulcer drug sucrose octasulfate (SOS) binds to fibroblast growth factors (FGFs), proteins which stimulate the growth and differentiation of several cell types, including stomach epithelial cells. It is believed that SOS stabilizes FGFs against acid denaturation in the stomach, thus enhancing their ability to stimulate healing of ulcerated tissue. SOS binds to the same site on...

The bacterial SOS stress-response pathway is a pro-mutagenic DNA repair system that mediates bacterial survival and adaptation to genotoxic stressors, including antibiotics and UV light. The SOS pathway is composed of a network of genes under the control of the transcriptional repressor, LexA. Activation of the pathway involves linked but distinct events: an initial DNA damage event leads to ac...

Plant phenology is changing because of recent global warming, and this change may precipitate changes in animal distribution (e.g., pests), alter the synchronization between species, and have feedback effects on the climate system through the alteration of biogeochemical and physical processes of vegetated land surface. Here, ground observations (leaf unfolding/first leaf separation of six deci...

System-of-Systems (SoS) have been considered the new trend of software systems for several reasons, such as the advancement of computer technology and the increasing complexity and size of the systems. The concept of SoS has the central idea of a set of operationally independent software systems that collaborate together to compose a larger and more complex system. For SoS, several quality attr...

As organizations strive to expand system capabilities through the development of system-ofsystems (SoS) architectures, they want to know “how much effort” and “how long” to implement the SoS. In order to answer these questions, it is important to first understand the types of activities performed in SoS architecture development and integration and how these vary across different SoS implementat...