An important step toward improving the annotation of the human genome is to identify cis-acting regulatory elements from primary DNA sequence. One approach is to compare sequences from multiple, divergent species. This approach distinguishes multispecies conserved sequences (MCS) in noncoding regions from more rapidly evolving neutral DNA. Here, we have analyzed a region of approximately 238kb ...

Two destructive high-frequency sea level oscillation events occurred on June 13th, 2013 along the U.S. East Coast. Seafloor processes can be dismissed as the sources, as no concurrent offshore earthquakes or landslides were detected. Here, we present evidence that these tsunami-like events were generated by atmospheric mesoscale convective systems (MCSs) propagating from inland to offshore. The...

In this paper, our goal is to compare different recent time-frequency (TF) approaches retrieve the modes of multicomponent signals (MCSs). While it acknowledged that synchrosqueezing transform (SST) improves readability representation (TFR) MCSs, and SST-based demodulation (DSST) more efficient than SST itself for mode retrieval (MR), unclear whether DSST outperforms downsampled short-time Four...

Viruses recruit cellular membranes and subvert cellular proteins involved in lipid biosynthesis to build viral replicase complexes and replication organelles. Among the lipids, sterols are important components of membranes, affecting the shape and curvature of membranes. In this paper, the tombusvirus replication protein is shown to co-opt cellular Oxysterol-binding protein related proteins (OR...

Computational fragment-based approaches are widely used in drug design and discovery. One of their limitations is the lack performance docking methods, mainly scoring functions. With emergence for single-stranded RNA ligands, we analyze screening powers an MCSS-based approach. The evaluated on a benchmark protein–nucleotide complexes where four residues as fragments. power can be considered maj...

In this study, we used hierarchical linear modeling to examine restricted-use 2011 National Assessment of Educational Progress (NAEP) data explore relationships between principal-reported time spent on the different NAEP responsibilities mathematics coaches and specialists (MCSs) achievement scores approximately 37,400 fourth-grade students in 1,500 U.S. elementary schools. The model included a...

This study identifies 38 cases of windthrows in the Amazonia to explore relationship between and characteristics (storm passing time, cloud top temperature, maximum precipitation) mesoscale convective systems (MCSs) that produced them. Most windthrow this occurred August September. The storm time is positively correlated with size windthrows. MCSs colder temperature (with a mean at 206 K)—indic...

Seismic probabilistic safety assessment (PSA) models for nuclear power plants (NPPs) have many non-rare events whose failure probabilities are proportional to the seismic ground acceleration. It has been widely accepted that minimal cut sets (MCSs) calculated from PSA fault tree should be converted into exact solutions, such as binary decision diagrams (BDDs), and accurate core damage frequency...

From 7 July to 11 2013, an extreme rainstorm occurred in the Sichuan Basin (SCB) of China, which is located at eastern edge Tibetan Plateau, causing severe floods and huge economic losses. The event was associated with mesoscale convection systems (MCSs). In this paper, we analyze evolution characteristics formation conditions MCSs, results show that: (1) continuous activity MCSs a direct cause...

Abstract. Our knowledge of the properties precipitation and clouds over their life cycles has progressed with rapid development satellite observations. However, previous studies have focused on cycle evolution macroscale features clouds, whereas microphysical is yet to be determined. One reasons for this lack fact that there no single dataset providing both three-dimensional structure relevant ...