Inhaled corticosteroids (ICSs) are widely prescribed in chronic obstructive pulmonary disease (COPD). However, little is known about predictors of ICSs therapeutic response. To investigate whether the variation in glucocorticoid-induced transcript 1 (GLCCI1) rs37973 is associated with ICS efficacy. A total of 204 clinically stable COPD patients were recruited and administered to inhaled flutica...

Integrated Control Systems (ICSs) are often large-scale and highly configurable software-intensive systems-of-systems, with software and hardware components integrated to control and monitor physical devices and processes (e.g., oil and gas production platforms). Employing Product Line Engineering (PLE) is believed to bring potential benefits with respect to reduced cost, higher productivity, h...

PURPOSE To clarify the relationship between asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS) and depression. METHODS We identified 10,911 patients who received an ACOS diagnosis and concurrent treatment between January 2000 and December 2009. Subjects without ACOS were included in the non-ACOS cohort (n = 10,911). Cox proportional hazard regression analysis was performed t...

The present experiment assessed whether prenatal stress (PS) can alter the ability of acute and chronic cocaine administration to increase and decrease the rewarding effectiveness of the medial forebrain bundle (MFB) using intracranial self-stimulation (ICSS), and also whether PS can affect the extinction of the MFB stimulation response. Adult male offspring of female rats that received PS or n...

Dysregulated dopamine transmission in striatal circuitry is associated with impulsivity. The current study evaluated the influence of dopaminergic inputs to the dorsolateral striatum on impulsive choice, one aspect of impulsive behavior. We implemented an operant task that measures impulsive choice in rats via delay discounting wherein intracranial self-stimulation (ICSS) was used as the positi...

OBJECTIVES This study aims to assess voice changes and laryngeal abnormalities in asthmatic patients using inhaled corticosteroids (ICSs). PATIENTS AND METHODS This study included 30 patients (15 females; mean age 21.3±2.6 years; range, 17 to 26 years and 15 males; mean age 20.7±2.3 years; range, 16 to 27 years) with bronchial asthma treated with ICSs between May 2013 and December 2013. A spe...

The index datewas defined as the date of the first indicator of diabetes for cases and the date of selection for controls. The dose of ICSs was categorized as low (<251 mg/d, fluticasone propionate equivalents), medium (251-500 mg/d), high (>500 mg/d), or no use, and LABAwas classified as use (>_1 mg/d, salmeterol equivalents) or no use and measured on the index date. This study was approved by...

Abstract Owing to the development of industrial production, hidden danger in control systems (ICSs) has considerably increased, causing challenges traditional safety defense methods. The combination machine-learning or deep-learning algorithms and intrusion detection (IDSs) become mainstream method for solving this problem. However, these methods depend on a massive amount high-quality attack t...

Carotid artery stenting (CAS) has emerged as an alternative to endarterectomy (CEA) for treatment of atherosclerotic stenosis of the internal carotid artery. The International Carotid Stenting Study (ICSS) was a randomized trial comparing CAS with CEA in patients with symptomatic carotid stenosis. An analysis of short-term outcome data in ICSS revealed a significantly increased risk in the inci...

The involvement of metabotropic glutamate receptors (mGluRs) in hippocampal long-term potentiation (LTP) is a matter of controversial debate. Using [Ca2+]i measurements by confocal laser scanning microscopy and field recordings of EPSPs (fEPSPs) in the hippocampal CA1-region, we found that the efficacy of the broad-spectrum mGluR-antagonist (S)-alpha-methyl-4-carboxyphenylglycine (MCPG) and of ...