Hyperglycemia-induced alterations in mesangial (MES) cell function and extracellular matrix protein accumulation are seen in diabetic glomerulopathy. Recent studies have demonstrated that some of the effects of high glucose (HG) on cellular metabolism are mediated by the hexosamine biosynthesis pathway (HBP), in which fructose-6-phosphate is converted to glucosamine 6-phosphate by the rate-limi...

Hexosamines have been shown to mediate effects of hyperglycemia and so-called "glucose toxicity" in insulin-sensitive tissues. To determine the effects of hexosamines on insulin synthesis and secretion, transgenic mice were created to overexpress the rate-limiting enzyme for hexosamine synthesis, glutamine:fructose-6-phosphate amidotransferase (GFA), specifically in beta-cells. GFA activity in ...

BACKGROUND The Millard method of unilateral cleft lip repair has been associated with a short lip and a flattened nose on the cleft side. The aim of this study was to determine the need for revision surgery following repair of unilateral cleft lip repair at the Komfo Anokye Teaching Hospital. METHOD Satisfaction with facial appearance (upper lip, nose and general facial appearance) was assess...

The paper examines communication and visibility (C&V) aspect in the operations of EU Delegation Saudi Arabia GFA Consulting Group. author assumes that properly designed using adequate contents may significantly affect external relations. To verify this statement, twofold approach was used. First, through lens Soft Power actorness, it looks into theoretical dimension international relations ...

In this study, we conducted two surveys in the central and southern parts of South China Sea, autumn 2012 spring 2013. Six juvenile tuna species were caught each survey. Gradient forest analysis (GFA) a generalized additive model (GAM) used to analyze relationship between catch per unit effort (CPUE) for six sea temperature indices Sea. GFA, difference surface 50 m depth (D50) showed highest im...

A three-dimensional quantitative structure-activity relationship (3D QSAR) study has been carried out on epothilones based on comparative molecular field analyses (CoMFA) using a large data set of epothilone analogs, which are potent inhibitors of tubulin depolymerization. Microtubules, which are polymers of the a/beta-tubulin heterodimer, need to dissociate in order to form the mitotic spindle...

In the present study, we examine a worm-like micelle consisting of a nonionic surfactant system of polyoxyethylene phytosterol (PhyEO(m))/glycerin fatty acid monoester (GFA-C(n))/Water (m=10, 20, 30; n=8, 10, 12) using rheological measurements looking towards potential application of the system as a gel base. Phase diagrams in the dilute region of the PhyEO(m)/GFA-C(n)/Water systems show the fo...

Abstract Extra temporal lobe epilepsy (eTLE) may involve heterogenous widespread cerebral networks. We investigated the structural network of an eTLE cohort, at postulated epileptogenic zone later surgically removed, as a node; resection (RZ). hypothesised patients with abnormal connection to/from RZ, to have proportionally increased abnormalities based on topological proximity in addition poor...

Topoisomerase 1 (top1) inhibitors are proving useful against a range of refractory tumors, and there is considerable interest in the development of additional top1 agents. Despite crystallographic studies, the binding site and ligand properties that lead to activity are poorly understood. Here we report a unique approach to quantitative structure-activity relationship (QSAR) analysis based on t...