Munzenmaier, Diane H., and David R. Harder. Cerebral microvascular endothelial cell tube formation: role of astrocytic epoxyeicosatrienoic acid release. Am J Physiol Heart Circ Physiol 278: H1163–H1167, 2000.—Cerebral microvascular endothelial cells (CMVEC) form tubes when cocultured with astrocytes (AS). Therefore, it appears that AS may be important in mediating angiogenesis in the brain. We ...

Toyoda, Kazunori, Frank M. Faraci,Andrew F. Russo, Beverly L. Davidson, and Donald D. Heistad. Gene transfer of calcitonin gene-related peptide to cerebral arteries. Am. J. Physiol. Heart Circ. Physiol. 278: H586–H594, 2000.—Overexpression of calcitonin gene-related peptide (CGRP), an extremely potent vasodilator, to blood vessels is a possible strategy for prevention of vasospasm. We construct...

Kuryshev, Yuri A., Tatyana I. Gudz, Arthur M. Brown, and Barbara A. Wible. KChAP as a chaperone for specific K1 channels. Am J Physiol Cell Physiol 278: C931–C941, 2000.—The concept of chaperones for K1 channels is new. Recently, we discovered a novel molecular chaperone, KChAP, which increased total Kv2.1 protein and functional channels in Xenopus oocytes through a transient interaction with t...

Johnston, Sonya D., Sandra Orgeig, Olga V. Lopatko, and Christopher B. Daniels. Development of the pulmonary surfactant system in two oviparous vertebrates. Am. J. Physiol. Regulatory Integrative Comp. Physiol. 278: R486– R493, 2000.—In birds and oviparous reptiles, hatching is often a lengthy and exhausting process, which commences with pipping followed by lung clearance and pulmonary ventilat...

JOHN G. HOHMANN,1 THOMAS H. TEAL,2 DONALD K. CLIFTON,2 JAMES DAVIS,3 VICTOR J. HRUBY,4 GUOXIA HAN,4 AND ROBERT A. STEINER2,5 1Graduate Program in Neurobiology and Behavior, Departments of 2Obstetrics and Gynecology and 5Physiology and Biophysics, University of Washington, Seattle, Washington 98195; 3Amgen Corporation, Thousand Oaks, California 91320; and 4Department of Chemistry, University of ...

Molitoris, Bruce A., Joel M. Weinberg, Manjeri A. Venkatachalam, Richard A. Zager, Karl A. Nath, and Michael S. Goligorsky. Acute renal failure. II. Experimental models of acute renal failure: imperfect but indispensable. Am. J. Physiol. Renal Physiol. 278: F1–F12, 2000.—Acute renal failure (ARF) due to ischemic1 or toxic renal injury, a clinical syndrome traditionally referred to as acute tubu...

Wang, Danzhao, Hideaki Yoshida, Qing Song, Lee Chao, and Julie Chao. Enhanced renal function in bradykinin B2 receptor transgenic mice. Am. J. Physiol. Renal Physiol. 278: F484–F491, 2000.—The tissue kallikrein-kinin system has been recognized as a paracrine and/or autocrine hormonal system that regulates arterial pressure, renal hemodynamics, and electrolyte excretion. We have created a transg...

Kanashiro, Celia A., Kathy L. Cockrell, Barbara T. Alexander, Joey P. Granger, and Raouf A. Khalil. Pregnancy-associated reduction in vascular protein kinase C activity rebounds during inhibition of NO synthesis. Am. J. Physiol. Regulatory Integrative Comp. Physiol. 278: R295– R303, 2000.—Vascular reactivity has been shown to be reduced during pregnancy and to be enhanced during chronic inhibit...

Iwasaki, Hiroaki, Satoru Eguchi, Hikaru Ueno, Fumiaki Marumo, and Yukio Hirata. Mechanical stretch stimulates growth of vascular smooth muscle cells via epidermal growth factor receptor. Am. J. Physiol. Heart Circ. Physiol. 278: H521–H529, 2000.—We have studied whether activation of epidermal growth factor receptor (EGFR) is involved in stretch-induced extracellular signal-regulated kinase 1/2 ...

Sir, Özcan, Nadeem Fazal, Mashkoor A. Choudhry, Richard L. Gamelli, and Mohammed M. Sayeed. Neutrophil depletion prevents intestinal mucosal permeability alterations in burn-injured rats. Am J Physiol Regulatory Integrative Comp Physiol 278: R1224–R1231, 2000.—Cutaneous thermal injury increases intestinal mucosal permeability. The mechanisms of this functional disturbance are not fully understo...