Paclitaxel is a common chemotherapeutic agent that is effective against various cancers. The poor aqueous solubility of paclitaxel necessitates a large percentage of Cremophor EL:ethanol (USP) in its commercial formulation which leads to hypersensitivity reactions in patients. We evaluate the use of a crystalline nanosuspension versus the USP formulation to deliver paclitaxel to tumor-bearing x...

The representativeness of the Arquivos Brasileiros de Cardiologia for Brazilian Cardiology Science Paulo Roberto Barbosa Evora1 e Luiz Felipe P. Moreira2 Department of Surgery and Anatomy of Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo (USP)1, Ribeirão Preto; Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo (USP)2, São Paulo, SP...

Desferal, deferoxamine mesylate USP, is an iron-chelating agent, available in vials for intramuscular, subcutaneous, and intravenous administration. Desferal is supplied as vials containing 500 mg and 2 g of deferoxamine mesylate USP in sterile, lyophilized form. Deferoxamine mesylate is N-[5-[3-[(5­ aminopentyl)hydroxycarbamoyl]propionamido]pentyl]-3-[[5-(N­ hydroxyacetamido)pentyl]carbamoyl]p...

The front chamber of LUPRON DEPOT 3.75 mg prefilled dual-chamber syringe contains leuprolide acetate (3.75 mg), purified gelatin (0.65 mg), DL-lactic and glycolic acids copolymer (33.1 mg), and D-mannitol (6.6 mg). The second chamber of diluent contains carboxymethylcellulose sodium (5 mg), D-mannitol (50 mg), polysorbate 80 (1 mg), water for injection, USP, and glacial acetic acid, USP to cont...

We transform the 3D underwater positioning problem into its 2D counterpart via a projection technique that employs depth information available to underwater sensors. After showing that a non-degenerative projection preserves network localizability, we present a purely distributed localization scheme termed USP for underwater acoustic sensor networks. In USP, reference nodes are projected to the...

Trabalho realizado na Clínica Oftalmológica do Hospital das Clínicas da FMUSP São Paulo (SP) Brasil. 1 Pós-graduando do Departamento de Plástica Ocular do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo USP São Paulo (SP) Brasil. 2 Vitreous and Retina Clinical Fellow, University of California Irvine USA. 3 Chefe do Departamento de Glaucoma do Hospital das Clínicas da...

1 M.D., Professor of the Forensic Medicine, Medical Ethics, and Social and Work Medicine Department of Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil 2 Ph.D. in Odontological Sciences Professor of Universidade Santa Cecília, São Paulo, SP, Brazil 3 Ph.D. in Preventive Odontology– Professor of post-graduation in Forensic Medicine of Universidade de São Paulo – USP, São P...

The family of ubiquitin (Ub)-specific proteases (USP) removes Ub from Ub conjugates and regulates a variety of cellular processes. The human genome contains many putative USP-encoding genes, but little is known about USP tissue distribution, pattern of expression, activity, and substrate specificity. We have used a chemistry-based functional proteomics approach to identify active USPs in normal...

Ubiquitin-mediated endocytosis and post-endocytic trafficking of glutamate receptors control their synaptic abundance and are implicated in modulating synaptic strength. Ubiquitination is a reversible modification, but the identities and specific functions of deubiquitinating enzymes in the nervous system are lacking. Here, we show that the deubiquitinating enzyme ubiquitin-specific protease-46...

Synthetic nonsteroidal ecdysone agonists, a class of insect growth regulators (IGRs), target the ecdysone receptor (EcR), which forms a heterodimer with ultraspiracle (USP) to transactivate ecdysone response genes. These compounds have high binding affinities to the EcR-USP complexes of certain insects and their toxicity is selective for certain taxonomic orders. In the present study, we develo...