نتایج جستجو برای: احیایin vivo

تعداد نتایج: 331386  

2013
Issa Ibraheem

This paper proposes a novel approach for the automatic detection of allergy test (allergy lesion). A hyperspectral microscope system was used to image the test samples which were diagnosed by dermatologist. It was found that allergy of different levels, and healthy skin cells show absorption spectra, which are sufficiently characteristic and yet reproducible enough to allow for differentiation ...

Journal: :Journal of biomedical optics 2011
Tong Wu Zhihua Ding Chuan Wang Minghui Chen

A high speed swept source optical coherence tomography (SS-OCT) system capable of full-range imaging is presented. Wave-number carrier frequency is introduced into the spectral interference signal by a transmissive dispersive optical delay line (TDODL). High carrier frequency in the spectral interference signal corresponding to an equivalent distance-shift is exploited to obtain full-range OCT ...

Journal: :Journal of biomedical optics 2007
Leonardo Sacconi Rodney P O'Connor Audrius Jasaitis Alessio Masi Mario Buffelli Francesco S Pavone

Two-photon microscopy has been used to perform high spatial resolution imaging of spine plasticity in the intact neocortex of living mice. Multiphoton absorption has also been used as a tool for the selective disruption of cellular structures in living cells and simple organisms. In this work, we exploit the spatial localization of multiphoton excitation to perform selective lesions on the neur...

Journal: :Journal of biomedical optics 2012
Rupananda J Mallia Patrick Z McVeigh Israel Veilleux Brian C Wilson

As molecular imaging moves towards lower detection limits, the elimination of endogenous background signals becomes imperative. We present a facile background-suppression technique that specifically segregates the signal from surface-enhanced Raman scattering (SERS)-active nanoparticles (NPs) from the tissue autofluorescence background in vivo. SERS NPs have extremely narrow spectral peaks that...

2009
Bojana Gligorijevic Dmitriy Kedrin Jeffrey E Segall John Condeelis Jacco van Rheenen

In the last decade, intravital microscopy of breast tumors in mice and rats at single-cell resolution has resulted in important insights into mechanisms of metastatic behavior such as migration, invasion and intravasation of tumor cells, angiogenesis, and immune cells response. We have recently reported a technique to image orthotopic mammary carcinomas over multiple intravital imaging sessions...

2016
Chaejeong Heo Hyejin Park Yong-Tae Kim Eunha Baeg Yong Ho Kim Seong-Gi Kim Minah Suh

Chronic in vivo imaging and electrophysiology are important for better understanding of neural functions and circuits. We introduce the new cranial window using soft, penetrable, elastic, and transparent, silicone-based polydimethylsiloxane (PDMS) as a substitute for the skull and dura in both rats and mice. The PDMS can be readily tailored to any size and shape to cover large brain area. Clear...

Journal: :Journal of visualized experiments : JoVE 2014
Patrick D McGurk C Ben Lovely Johann K Eberhart

Time-lapse imaging is a technique that allows for the direct observation of the process of morphogenesis, or the generation of shape. Due to their optical clarity and amenability to genetic manipulation, the zebrafish embryo has become a popular model organism with which to perform time-lapse analysis of morphogenesis in living embryos. Confocal imaging of a live zebrafish embryo requires that ...

Journal: :Optics express 2009
Christoph J Engelbrecht Werner Göbel Fritjof Helmchen

Nonlinear microscopy techniques crucially rely on efficient signal detection. Here, we present a ring of large-core optical fibers for epi-collection of fluorescence photons that are not transmitted through the objective and thus normally wasted. Theoretical treatments indicated that such a supplementary fiber-optic light collection system (SUFICS) can provide an up to 4-fold signal gain. In ty...

2015
John R Eisenbrey Anush Sridharan Ji-Bin Liu Flemming Forsberg

Nonlinear contrast-enhanced ultrasound imaging schemes strive to suppress tissue signals in order to better visualize nonlinear signals from blood-pooling ultrasound contrast agents. Because tissue does not generate a subharmonic response (i.e., signal at half the transmit frequency), subharmonic imaging has been proposed as a method for isolating ultrasound microbubble signals while suppressin...

Journal: :Cancer biomarkers : section A of Disease markers 2008
Yun Xing Jianghong Rao

Semiconductor quantum dots are tiny light-emitting nanocrystals (2-10 nm) that have captivated researchers in the biomedical field in the last decade. Compared to organic dyes and fluorescent proteins, quantum dots (QDs) have unique optical properties such as tunable emission spectra, improved brightness, superior photostability, and simultaneous excitation of multiple fluorescence colors. Sinc...

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